摘要
目的分析糖尿病患者的尿素、肌酐、胱抑素C、β2-微球蛋白、微量白蛋白及糖化血红蛋白含量,以观察各项指标联合检测对糖尿病肾病早期诊断的临床意义。方法 80例糖尿病伴DN患者,87例糖尿病患者不伴DN,正常对照组为60例体检健康者。采用全自动生化分析仪测定BUN、Cr、CysC、β2-MG、尿微量白蛋白(m-Alb)及糖化血红蛋白(HbA1c)含量。结果糖尿病肾病组各项指标均明显高于正常对照组,差异有显著性(P<0.05),糖尿病肾病组与糖尿病组相比较,除HbAlc无统计学差异外,其余五项均高于糖尿病组,差异有显著性(P<0.05);糖尿病组和正常对照组比较,除HbAlc差异有显著性(P<0.05)外,其余5项均无统计学差异。且联合检测阳性率达100%,明显高于各指标单项检测。结论糖尿病患者联合检测BUN、Cr、CysC、β2-MG、mALb及HbAlc六项指标的水平,可以监测糖尿病肾病的发生和发展,对糖尿病患者肾损伤的早期诊断、治疗和预后有着重要临床意义。
【Objective】To explore UREA, Creatinine, Cystatin-C, β2-microglobulin, microalbumin and glycosylated haemoglobin levels of the diabebic patients in order to observe the clinical significance of the index of united detection of diabetic nephropathy. 【Methods】79 cases of diabetic patients with diabetic nephropathy; 86 cases of diabetic patients without diabetic nephropathy; The normal control group is 59 cases of healthy physical examines;【Results】The index of diabetic nephropathy group were significantly higher than that of normal control group, the difference was statistically significant（P〈0.05）. The index of diabetic nephropathy group, except HbAlc is no statistical difference, the other five indexes are higher compared with diabetes group, the difference was statistically significant（P〈0.05）; Diabetes group and the normal control group is, in addition to HbAlc＇s difference was statistically significant（P〈0.05）, and no statistically significant differences were found in the other five indexes. And the positive of joint test is 100%, much higher than the single detection of each index. 【Conclusions】The united detection of the six index BUN, Cr, CysC, β2-MG, mALb and HbAlc level for diabetes patients, can help to survey the origin and development of the diabetic nephropathy, and has important clinical significance in the early diagnosis、treatment and prognosis of renal injury for people with diabetes.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第30期49-52,共4页
China Journal of Modern Medicine
基金
湖南省社会发展支撑计划(No:2014SK3244)
湖南省自然科学基金项目(No:10c0054)
