摘要
目的:探讨复方续断接骨丸对四肢骨折愈合作用及对骨形态发生蛋白(BMP)、胰岛素样生长因子(IGF)和血管内皮生长因子(VEGF)的影响。方法:将90例四肢患者随机按数字表法分为对照组和观察组各45例。对照组服用阿法骨化醇,1粒/次,2次/d;观察组服用复方续断接骨丸,1丸/次,2次/d。两组疗程均为6周。记录两组疼痛、肿胀和瘀斑消失时间;采用X射线观察骨痂生长情况;检测治疗前后BMP,IGF,VEGF。结果:经Ridit分析,观察组临床骨折愈合疗效优于对照组(P<0.05);观察组疼痛、肿胀和瘀斑消失时间均短于对照组(P<0.01);治疗后6,8周,观察组骨痂生长情况评分均高于对照组(P<0.01);治疗后观察组BMP-2,IGF-I,IGF-Ⅱ和VEGF水平高于对照组(P<0.01)。结论:复方续断接骨丸促进了骨痂的形成,促进骨折的愈合,其作用机制可能是通过促进BMP-2,IGF-I,IGF-Ⅱ和VEGF等因子的表达来实现的。
Objective： To discuss the curative efficacy of Fufang Xuduan Jiegu pills on limbs fracture healing and the influence on bone morphogenetic protein（ BMP）,insulin-like growth factor（ IGF） and vascular endothelial growth factor（ VEGF）. Method： Ninety patients were randomly divided into control group（ 45 cases）and observation group（ 45 cases） by random number table. Patients in control group received one alfacalcidol twice daily and patients in observation group received one Fufang Xuduan Jiegu pills twice daily for 6 weeks. The disappeared times of pain,swelling and ecchymosis in two groups were recorded. The growth of callus was observed using X-ray. The levels of BMP,IGF and VEGF were detected before and after treatment. Result： The healing efficacy of clinical fractures in observation group was superior to that in control group（ P〈0.05） through ridit analysis. The disappeared times of pain,swelling and ecchymosis in observation group were shorter than those in control group（ P〈0.01）. Callus growth score in observation group was higher than that in control group at the sixth and eighth week after treatment（ P〈0.01）. Levels of BMP-2,IGF-I,IGF-Ⅱand VEGF in observation group were superior to those in control group（ P〈0.01）. Conclusion： Fufang Xuduan Jiegu pills could promote the formation of callus and the healing of fracture. The action mechanism may be achieved by accelerating the expression of BMP-2,IGF-I,IGF-Ⅱ and VEGF.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第22期220-223,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
2009年山东省优秀中青年科学家科研奖励基金计划医药卫生项目(2008BS02026)
关键词
骨折
复方续断接骨丸
骨形态发生蛋白
胰岛素样生长因子
血管内皮生长因子
fracture
Fufang Xuduan Jiegu pills
bone morphogenetic protein
insulin-like growth factor
vascular endothelial growth factor
