摘要
目的:探讨生大黄经鼻肠管灌注在急性胰腺炎中的应用的可行性和有效性。方法:选取2011年1月—2013年6月期间收治的107例急性胰腺炎患者作为研究对象,其中重症急性胰腺炎32例。以数字法随机分成观察组(55例)和对照组(52例)。观察组采用经鼻肠管灌注,对照组采用经胃管注入等量等温的生大黄液,对比两组APACHEⅡ评分、Balthazar CT积分、空肠到达率、不良反应率、成功率,以及C反应蛋白、血淀粉酶、肛门排气排便功能、腹疼消除及肠鸣音恢复时间,并观察两组治疗后IL-1、IL-6及细菌内毒素水平。结果:观察组的APACHEⅡ评分为(4.48±1.44)分,明显低于对照组的(5.32±1.04)分,差异有统计学意义(P<0.05),观察组Balthazar CT积分为(2.57±1.38)分,与对照组的(2.98±1.15)分对比,差异无统计学意义(P>0.05);观察组的12 h空肠到达率为74.55%、成功率为96.36%,显著高于对照组的50.00%、84.62%,差异均有统计学意义(均P<0.05);观察组的不良反应率为5.45%,显著低于对照组的21.15%,差异有统计学意义(P<0.05);两组24 h空肠到达率无明显差异(P>0.05);观察组患者的C反应蛋白、血淀粉酶、肛门排气排便功能、腹疼消除及肠鸣音恢复时间均显著高于对照组,差异均有统计学意义(均P<0.05);观察组血清IL-1、IL-6、细菌内毒素水平分别为(28.75±7.32)pg/mL、(33.56±8.12)pg/mL、(21.03±13.66)pg/mL,显著低于对照组的(34.77±7.70)pg/mL、(38.35±6.45)pg/mL、(33.25±10.14)pg/mL,差异均具有统计学意义(均P<0.05)。结论生大黄经鼻肠管灌注术对于急性胰腺炎患者的治疗能够有效地提高治愈率、减少对胰腺的刺激、缩短胃肠道功能的恢复时间,减少了不良反应的并发症,值得推广。
Objective：To evaluate the feasibility and effectiveness of the raw rhubarb nasal jejunal tube perfusion application of the acute pancreatitis. Methods：In our hospital from January 2011 to June 2013,107 cases of patients with acute pancreatitis were selected as the research object,including 32 cases of severe acute pancreatitis. By digital method,they were randomly divided into observation group （55 cases） and control group （52 cases）. Observation group used nasal jejunal tube perfusion and the control group used the stomach tube injection amount of isothermal raw rhubarb fluid. We compared two groups＇ APACHE Ⅱ score, Balthazar CT integral,jejunum arrival rate and adverse reaction rate, success rate as well as c -reactive protein, blood amylase, anus exhaust defecation function, stomach ache elimination and bowel sound recovery time and observed the two groups＇IL - 6 and IL - 1 bacterial endotoxin levels after treatment. Results ： The observation group＇ s APACHE Ⅱ score was （4.48 ±1.44） ,significantly lower than that of the control group （5.32 ± 1.04 ） and the difference was statistically significant （ P 〈 0.05 ）. The observation group＇ s Bahhazar CT （ 2.57 ± 1.38 ） points compared with control group＇s （2.98±1.15 ） points had no statistically significant difference （ P 〉 0.05 ）. 12 h jejunum arrival rate in observation group was 74.55% and the success rate was 96.36% , significantly higher than those of control group 50.00%, 84.62% and both had statistically significant differences （ all P 〈 0.05 ）. Observation group＇s adverse reaction rate was 5.45% , significantly less than 21.15% of the control group and the difference was statistically significant （P 〈 0.05 ）. No obvious difference was found between two groups of 24 h jejunum arrival rate （P 〉 0.05 ）. Observation group＇s blood c -reactive protein, amylase, anus exhaust defecation function, stomach ache elimination and bowel sounds recovery time were significantly higher than thos
出处
《中华中医药学刊》
CAS
2014年第11期2785-2787,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
生大黄
鼻肠管灌注
急性胰腺炎
应用价值
raw rhubarb
nasal jejunal tube perfusion
acute pancreatitis
application value
