摘要
目的探讨高血压患者血清胱抑素C(CysC)和N端脑钠肽前体(NT-proBNP)水平的变化。方法选取89例高血压患者并分为5个亚组:A组(20例),单纯性高血压组;B组(18例),高血压合并左心肥厚组;C组(15例),高血压合并心力衰竭组;D组(17例),高血压合并早期肾功能损害组;E组(19例),高血压合并冠心病组。并选取20例健康体检者作为对照组,测定各组血清CysC和NT-proBNP水平。结果 B、C、D组的CysC水平高于对照组,E组CysC水平低于对照组,差异均有统计学意义(P<0.05)。D组的NT-proBNP水平高于对照组(P<0.05),B、C、E组NT-proBNP水平显著高于对照组(P<0.01),差异均有统计学意义。结论测定高血压患者血清CysC和NT-proBNP水平可以了解病情的发展及合并疾病发生情况,为临床治疗提供依据。
Objective To investigate the changes of serum levels of CysC and NT-proBNP in patients with hypertension.Methods 89 patients with hypertension were selected and divided into five subgroups：Group A（n=20）with simple hypertension;Group B（n=18）with hypertension and left ventricular hypertrophy;Group C（n=15）with hypertension and heart failure;Group D（n=17）with hypertension and early renal damage;Group D（n=19）with hypertension and coronary heart disease.20 healthy individuals were selected as control group.The serum levels of CysC and NT-proBNP were measured in all the groups.Results The serum levels of CysC in group B,C and D were higher than control group（P〈0.05）,and serum CysC level in group E was lower than control group（P〈0.05）.The serum level of NT-proBNP in group D was higher than control group（P〈0.05）,and the serum NT-proBNP levels in group B,C and E were significantly higher than control group（P〈0.01）.Conclusion The detection of CysC and NT-proBNP in patients with hypertension is helpful for understanding the progression of the disease and the occurrence of amalgamative diseases,and it provides positive proof for clinical treatment.
出处
《国际检验医学杂志》
CAS
2014年第21期2885-2886,共2页
International Journal of Laboratory Medicine
关键词
高血压
胱抑素C
N端脑钠肽前体
hypertension
cystatin C
N-terminal pro-brain natriuretic peptid
