摘要
苯(benzene)是一种常见的职业性毒物和环境污染物,主要由其代谢产物氢醌(Hydroquinone,HQ)发挥毒性作用。聚腺苷二磷酸核糖聚合酶[Poly(ADP-ribose)polymerase,PARP]是一类存在于多数真核细胞内的多功能蛋白质翻译后修饰酶,其中PARP-l是研究最早、最为深入的一种。PARP-1在氢醌诱导细胞凋亡中发挥了重要作用。本文从HQ的概述、PARP-1的结构与功能以及PARP-1在HQ诱导细胞凋亡中的作用等方面做一综述,以期对苯暴露引起的各类疾病的防治提供理论指导。
Benzene was a common occupational toxicology and environmental pollutants,which mainly played toxicity by its metabolite hydroquinone. Poly（ ADP-ribose） polymerase was a latter category of multifunctional protein post-translational modification enzymes existing in the majority of eukaryotic cells,while PARP-1 was studied as the earliest and most thorough one. PARP-1 played an important role in the induction of cell apoptosis by hydroquinone. Outlines of the HQ,PARP-1 structure and function as well as aspects of PARP-1 role in the induction of cell apoptosis were reviewed,expecting to prevention and treatment of various diseases caused by benzene exposure and providing theoretical guidance.
出处
《广州化工》
CAS
2014年第21期3-5,17,共4页
GuangZhou Chemical Industry
基金
国家自然科学基金(81273116)
广东省自然科学基金(S2013010015153)
湛江市科技计划项目(2013B01082)
广东医学院科研基金(XK1414)
