摘要
微小核糖核酸(microRNAs,miRNA)是一类内源性高度保守的非编码小分子RNA,其可通过降解信使RNA并抑制其翻译在转录水平调控靶基因的表达,参与细胞生长、发育、分化和增殖等多个生命过程。MicroRNAs-126(miR-126)是一种内皮特异性miRNA,与高血压、动脉粥样硬化、冠心病、心力衰竭等心血管疾病密切相关。近期研究表明,miR-126能显著影响心血管疾病的发生、发展和疾病的预后。本文就miR-126与心血管疾病的关系进行综述。
MicroRNAs （miRNAs, miRNA） are a class of endogenous highly conserved, small, noncoding RNA molecules, which control the expression of genes at the post-transcriptional level through degradation of messenger RNA and inhibits its translation. They are involved in cell growth, development, differentiation, proliferation and other life processes. miR-126 is a kind of specific miRNA, which is closely related to hypertension, atherosclerosis, coronary heart disease, heart failure and other cardiovascular diseases. Recent studies have shown that miR-126 can significantly affect the incidence and development of cardiovascular diseases. More so, it can also influence the prognosis of cardiovascular diseases. In this paper, the relationship between miR-126 and cardiovascular diseases was reviewed.
出处
《心脏杂志》
CAS
2014年第6期724-726,733,共4页
Chinese Heart Journal
