摘要
目的:对不同温度干热气体导致犬喉部不同部位组织烧伤后的病理变化进行分析,并与临床分型进行对比分析。方法:用18只成年公犬建立动物模型,吸入80℃、160℃和320℃的干热气体,吸入时间为20 min,然后取会厌、喉前庭、声襞、气管的不同部位组织进行病理学观察。结果:80℃组的组织病理主要表现为局部黏膜萎缩样改变,160℃组以喉部黏膜下组织的中度水肿变化为主,320℃组有重度水肿型及萎缩硬化型两种病理改变。结论:喉部由于其特殊的解剖和功能,对不同温度的热气损伤反应不一,通过病理学上的观察和分析可以看出,80℃组、160℃组的喉烧伤的病理改变基本符合充血型及水肿型的喉镜表现,而320℃组却有重度水肿型及萎缩硬化型两种不同的病理改变,故喉烧伤的病理学分析作为临床分型的补充有着重要意义。
Objective：To examine pathological changes in different parts of the larynx in canines after laryngeal burns induced by hot dry air at various temperatures and compare the pathological results with clinical typing. Methods： Eighteen healthy,male,adult dogs were randomly assigned to inhale hot dry air at 80 ℃（Group 1）,160 ℃（Group 2） or 320 ℃（Group 3） for 20 min to induce inhalation injury.Pathological changes after hot air inhalation were examined at different locations of the larynx including the epiglottis,laryngeal vestibule,vocal folds and trachea. Results： Pathological changes were mainly characterized by local mucosal atrophy in the larynx in Group 1 and moderate edema in the laryngeal submucosa in Group 2. Group 3 showed two types of pathological changes in the larynx： severe edema as well as atrophy and charring. Conclusion： Due to its special anatomy and functions,the larynx has different responses to inhalation injuries induced by hot air at different temperatures. The pathological observation and analysis showed that the pathological changes brought about by laryngeal burns at 80 ℃and 160 ℃ were generally consistent with laryngoscopic manifestations of congestion and edema. Inhalation of hot dry air at 320 ℃ led to two types of pathological changes,severe edema and atrophy and charring. Hence,pathological analysis of laryngeal burns may be used as a supplemental tool to clinical typing.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2014年第5期771-776,共6页
Journal of Peking University:Health Sciences
基金
国家自然科学基金(81071550)
首都特殊临床医学技术发展研究基金(Z090507017709008)资助~~
关键词
喉
烧伤
吸入性
病理过程
模型
动物
Larynx
Burns
inhalation
Pathologic processes
Models animal
