摘要
微小RNA（microRNA,miRNA）是一类长22个核苷酸左右,通过与靶基因信使RNA（messenger RNA,mRNA）3′UTR（非翻译区）配对结合,来调控靶基因生物学作用的非编码RNA。肿瘤细胞中也有miRNA的表达,它与肿瘤的发生、发展以及某些生物学特性密切相关。
MicroRNAs are a class of small（-22nt）non-coding RNAs that bind to the 3′untranslated regions（3′-UTRs）of their target mRNAs in a complementary or partially complementary manner via the seed sequence in their 5′-region to regulate biological effect.MicroRNAs also expressin malignant tumors and have close relations with occurrence,development and other biological characteristics of tumor.The effect of radiotherapy and the prognosis of cancer patients are limited and influenced by radioresistant all the time.In recent years,the application of microRNAs to improve the radiation sensitivity of tumor cells is a new field in tumor biotherapy.This paper mainly reviews the identification of related microRNAs participating in and regulating the formation of radiosensitivity/radioresistent,and the research progress of their possible mechanisms.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2014年第21期1721-1726,共6页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
浙江省科技计划项目"靶向喉癌干细胞的新型放射增敏剂的开发研究"(No:2010C33006)
