摘要
目的对比齐拉西酮和利培酮对男性精神分裂症患者性激素水平的影响。方法选择60例男性精神分裂症患者随机分为研究组(n=30)和对照组(n=30),分别给予齐拉西酮(105±7.4)mg·d-1和利培酮(3.6±0.8)mg·d-1治疗4周,于治疗前和治疗28 d后采用电化学发光免疫分析技术测定催乳素、雌二醇、睾酮和孕酮水平,同时用阳性和阴性症状量表(PANSS)评定精神症状。结果治疗前两组催乳素、雌二醇、睾酮和孕酮水平及PANSS分值相比均无显著差异(P>0.05)。与治疗前相比,治疗后研究组催乳素水平[(14.32±3.95)vs.(16.38±8.56)ng·m L-1]略有升高,但差异无显著意义(P>0.05),雌二醇、睾酮和孕酮水平无明显变化(P>0.05);治疗后对照组催乳素[(15.31±2.22)vs.(55.18±15.43)ng·m L-1]、雌二醇[(91.13±24.22)vs.(99.08±18.69)pg·m L-1]、睾酮[(6.21±1.68)vs.(7.01±1.10)ng·m L-1]水平明显升高(P<0.05或P<0.01),孕酮水平无显著变化[(1.52±0.56)vs.(1.55±0.63)ng·m L-1,P>0.05]。两组患者PANSS分值均较治疗前明显降低(P<0.01),治疗后两组PANSS分值组间比较无显著差异(P>0.05)。结论齐拉西酮对男性精神分裂症患者性激素的影响小于利培酮,而疗效相当。
AIM To compare the effect of ziprasidone with risperdal on the levels of sexual hormone in male schizophrenic patients. METHODS Totally 60 male schizophrenic patients were divided into two groups randomly as study group（ n = 30） and control group（ n = 30）, and ziprasidone（ 105 ± 7.4） mg·d-1and risperdal（ 3.6 ± 0.8） mg·d-1were prescribed respectively for 4 weeks. The symptoms of all patients were assessed with the Positive and Negative Syndrome Scale（PANSS） and the serum levels of estradiol, prolactin,testosterone and progesterone of all patients were measured with electro- chemiluminescence immune baseline and after 4 weeks treatment respectively. RESULTS There were no significant differences in the level of prolactin,estradiol, testosterone and progesterone as well as the scores of PANSS between the two groups before the treatment（P〈0.05）. Compared with before the treatment, the level of serum prolactin in the study group was higher than that after the treatment（14.32 ± 3.95） vs.（16.38 ± 8.56） ng·m L-1） but there was no significant difference（ P〈0.05）. There were no significant differences in the levels of estradiol, testosterone and progesterone in the study group between before and after the treatment（ P〈0.05）. The levels of prolactin[（15.31 ± 2.22） vs.（55.18±15.43） ng·m L-1], estradiol [（91.13 ± 24.22） vs.（99.08 ± 18.69） pg·m L-1] and testosterone [（6.21 ± 1.68） vs.（7.01 ± 1.10） ng·m L-1] in the control group after treatment were higher than those before the treatment（ P〈0.05 or P〈0.01）, but there was no significant difference in progesterone[（1.52±0.56） vs（1.55±0.63） ng·m L-1, P〈0.05]. The scores of PANSS in two groups after the treatment were decreased compared with before treatment and there were significant differences（ P〈0.01）. There was no significant difference in the scores of PANSS between two groups after the treatment（P〈0.05）. CONCLUSION Ziprasidone has less effect on sexual horm
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2014年第10期770-773,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
齐拉西酮
利培酮
雌二醇
催乳素
睾酮
孕酮
ziprosidone risperdal estradiol prolactin testosterone progesterone
