摘要
目的:探讨以咽部异物感为主要临床表现的反流性食管炎患者的临床治疗效果.方法:将2012-01/2014-06承德市中心医院收治的反流性食管炎患者进行分组治疗,治疗组患者主要以咽部异感为主要临床表现,共计75例;对照组患者主要临床表现中无咽部异物感,共计172例.两组均给予噢美拉唑治疗,比较两组患者治疗前后临床疗效、内镜分级改变、主要临床症状的改善情况等.结果:治疗组疼痛(87.8%vs 12.2%)、反流(62.2%vs 10.5%)、口苦(52.9%vs 6.4%)、咽部异物感(13.5%vs 1.2%)、吞咽困难(16.9%v s 2.3%)、恶心呕吐(34.3%v s4.1%)、胸部憋闷感(17.4%v s 1.7%)和对照组疼痛(21.3%vs 4.0%)、反流(38.7%vs9.3%)、口苦(22.7%v s 2.7%)、咽部异物感(100%vs 12.0%)、吞咽困难(85.3%vs8.0%)、恶心呕吐(68.0%vs 6.7%)、胸部憋闷感(18.7%vs 1.3%)临床症状上均有明显减少,治疗后与治疗前比较,差异有统计学意义(P<0.05).治疗组总有效率为75.6%,对照组总有效率为80%,组间差异无统计学意义(P>0.05).结论:以咽部异物感为主要临床表现的反流性食管炎患者在采取噢美拉唑治疗后有好的临床症状改善,其临床疗效与其他反流性食管炎患者相当.
AIM： To investigate the therapeutic effects of omeprazole in reflux esophagitis patients with foreign body sensation in the throat as the main clinical manifestation.METHODS： The patients with reflux esopha- gitis treated at our hospital from January 2012 to June 2014 were divided into two groups： an observation group and a control group （n = 172）. The observation group comprised 75 patients with foreign body sensation in the throat as the main clinical manifesta- tion, while the control group comprised 172 patients in whom foreign body sensation in the throat was not as the main clinical mani- festation. Both groups accepted orneprazole treatment. The clinical efficacy, endoscopic classification changes, and improvement of clinical symptoms were compared betweenbefore and after treatment and between the two groups.RESULTS： After treatment, the percentages of patients with pain （87.8% vs 12.2%）, regurgita- tion （62.2% vs 10.5%）, bitter taste in the mouth （52.9% vs 6.4%）, foreign body sensation in the throat （13.5% vs 1.2%）, dysphagia （16.9% vs 2.3%）, nausea and vomiting （34.3% vs 4.1%）, and chest distress （17.4% vs 1.7%） in the obser- vation group and those in the control group （21.3% vs 4.0%, 38.7% vs 9.3%, 22.7% vs 2.7%, 100% vs 12.0%, 85.3% vs 8.0%, 68.0% vs 6.7%, 18.7% vs 1.3%） were significantly reduced （P 〈 0.05）. The total effective rate was 75.6% in the treatment group and 80.0% in the control group, and there was no significant difference between the two groups （P 〉 0.05）.CONCLUSION： Omeprazole can achieve com- parable clinical effects between reflux esopha- gitis patients with pharyngeal foreign body sensation as the main clinical manifestation and those in whom foreign body sensation in the throat is not as the main clinical manifes- tation.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第27期4119-4123,共5页
World Chinese Journal of Digestology
关键词
反流性食管炎
咽部异物感
临床观察
Reflux esophagitis, Foreign body sen- sation
Clinical observation
