摘要
目的观察LFHD、HFHD及HDF三种血液净化方法对MHD患者微炎症状态的影响。方法将125例MHD患者根据血液净化方法分为三组:低通量血液透析(LFHD)组42例、高通量血液透析(HFHD)组41例和血液透析滤过(HDF)组42例。观察各组患者的CRP、IL-6、IL-8及TNF-α水平。结果 LFHD组患者透析前、首次透析后及透析6个月后的CRP、IL-6、IL-8及TNF-α水平无显著性差异(P>0.05);HFHD组患者透析6个月后CRP、IL-6、IL-8及TNF-α水平较透析前显著下降(P<0.01);HDF组首次透析后及透析6个月后CRP、IL-6、IL-8及TNF-α水平较透析前显著下降(P<0.01);HDF组透析6个月后CRP、IL-6、IL-8及TNF-α水平显著低于HFHD组(P<0.01)。结论 HDF治疗及长期的HFHD治疗均能有效的改善MHD患者的微炎症状态,且HDF治疗的效果好于HFHD治疗。
Objective To study the effects of LFHD, HFHD and HDF on the serum inflammatory cytokine in mainte- nance hemodialysis（MHD） patients. Methods A total of 125 MHD patients were divided into LFHD group（42 cases）, HFHD group （41 cases） and HDF group （42 cases）.CRP, IL-6, IL-8 and TNF-cdevels of all groups were detected. Results CRP, IL-6, IL-8 and TNF-alpha levels of LFHD group before dialysis, after the first time dialysis and after six months showed no significant difference （P〈0.05）. CRP, IL-6, IL-8 and TNF-α of HFHD group after six months dialysis significant decreased compared with before dialysis, P〈0.01; CRP, IL-6, IL-8 and TNF-α levels of HDF group of after the first and 6 months dialysis were significant lower than before dialysis（P〈0.01）; CRP, IL-6, IL-8 and TNF- α levels of HDF group after 6 month dialysis was significantly lower than HFHD group （P〈0.01）. Conclusion HDF treatment and long-term HFHD treatment can effectively improve micro inflammation in MHD patients, and the effica- cy of HDF is better than HFHD treatment.
出处
《中国现代医生》
2014年第31期24-26,共3页
China Modern Doctor
