摘要
报道了2-甲基-1,8-萘啶衍生物的甲基溴化反应,以N-溴代琥珀酰亚胺(NBS)为溴化剂、红外光为引发剂,得到单溴代产物2-溴甲基-1,8-萘啶衍生物及其二溴代副产物2-二溴甲基-1,8-萘啶衍生物,对比了两种不同的反应条件,通过对影响甲基溴化产物产率的反应条件进行优化改进,得到单溴代产物的较优合成条件为:NBS的用量为原料的1.2倍,500 W红外灯为光源,反应时间为2 h。该反应条件下,单溴代产物的产率可达到54.6%。
This paper reported the bromination of 2-methyl-I, 8-naphthyridine derivatives. Monobrominated products, 2-bromomethyl-1,8-naphthyridine derivatives, and dibrominated byproducts were obtained with N-bromosuccimide （NBS） as the bromination agent under infrared light. Two synthetic conditions were evaluated. The yield of monobrominated products is up to 54. 6% under the optimized condition of 2-methyl- 1,8-naphthyrdine derivatives and NBS in molar ratio of 1 ： 1.2 under 500 W infrared light.
出处
《应用化学》
CAS
CSCD
北大核心
2014年第11期1268-1272,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目(61361002)
云南省应用基础研究计划自筹项目(2013FZ121)
云南省化学硕士点建设学科资助项目(HXZ1303)~~
