摘要
目的探讨尿微量清蛋白(mALB)、α1-微球蛋白(α1-M)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG)检测在诊断肾脏早期损伤中的意义。方法以63例糖尿病患者(糖尿病组),58例高血压患者(高血压组)和64例健康体检者(对照组)为研究对象,采用免疫散射比浊法检测尿液中mALB、α1-M水平,采用终点比色法测尿液中NAG活性。结果糖尿病组和高血压组尿液中mALB、α1-M水平和NAG活性均高于对照组,差异有统计学意义(P<0.05)。糖尿病组和高血压组尿液中mALB、α1-M水平和NAG活性的单项检测阳性率均低于50.0%,任意2项指标联合检测的阳性率均高于50.0%,3项指标联合检测的阳性率则高于70.0%。结论尿液中mALB、α1-M及NAG联合检测是诊断肾脏早期损伤的敏感指标。
Objective To explore the diagnosis value of joint detection of microalbumin（mALB） ,α1-Microglolin（α1-M ） and N-acety-β-D-glucosaminidase（NAG） in the diabetes and hypertension patients with early injury of kidney .Methods Sample were col-lected from July 2013 to January 2014 ,including 63 diabetic cases（diabetic group） ,58 patients with hypertension（hypertension group） and 64 health controls（control group） ,then the levels of urinary mALB ,α1-M were detected by immunoturbidimetry ,urina-ry NAG activity was assessed by endpoint colorimetric assay .Results The levels of urinary mALB ,α1-M and NAG in diabetic group and hypertension group were higher than those in control group（P〈0 .05） .The positive rates of three indices single detected were less than 50 .0% ,the positive rates of any two indices joint detected were more than 50 .0% ,the positive rate of three indices joint detected was more than 70 .0% .Conclusion The method of urinary mALB ,α1-M and NAG joint detected is sensitive and reli-able for diagnosing of the early injury of kidney .
出处
《国际检验医学杂志》
CAS
2014年第19期2620-2621,共2页
International Journal of Laboratory Medicine
