摘要
地球自转产生了昼夜明暗交替循环,为了适应这一环境,生物体进化出时钟系统,控制着行为和生理进程同步化于光线的周期变化,以使能量利用达到最优状态.时钟的分子结构分级组建,其中中枢时钟掌管着进食/禁食之间的日际转换,而外周时钟导致能量储存/利用的24 h周期振荡.最近的研究表明,生物时钟响应于营养信号,而且高脂饮食影响了动物自发运动的周期(时钟的核心特质之一).生物时钟研究的一个主要目标是阐明代谢和时钟通路的交互对话.在本综述中,我们将讨论激素和作为营养信号的大分子如何整合时钟和代谢系统.
The circadian system synchronizes behavioral and physiological processes with daily changes in the external light-dark cycle,optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically,with neural clocks orchestrating the daily switch between periods of feeding and fasting,and peripheral clocks generating 24 h oscillations of energy storage and utilizations. Recent studies indicate that clocks respond to nutrient signals,and that high-fat diet influences the period of locomotor activity under free-running conditions,a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relationship between metabolic and circadian pathways. In this review,we will discuss the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems.
出处
《南京师大学报（自然科学版）》
CSCD
北大核心
2014年第3期1-7,共7页
Journal of Nanjing Normal University(Natural Science Edition)
基金
科技部973重点基础研究发展计划(2012CB947600、2013CB911600)
国家自然科学基金(31171137、31271261)
教育部新世纪优秀人才支持计划(NCET-11-0990)
关键词
生物时钟
能量代谢
营养信号
整合
circadian clock
energy metabolism
nutrient signals
integration
