摘要
目的:测定急性冠状动脉综合征患者血浆和肽素及肌钙蛋白(cTn)I浓度变化及与冠状动脉病变程度的关系。方法:疑似冠心病并行冠状动脉造影者(120例)随机分为急性心肌梗死(AMI,43例)组,心绞痛(AP,37例)组和非心源性胸痛(NCCP,40例)组;又按冠状动脉狭窄程度分为三支(28例)、双支(23例)、单支(21例)及左主干(8例)病变组,另设40例为对照组。用ELISA检测血浆和肽素水平,固定层析免疫法测定cTnI水平。结果:AMI组血浆和肽素及cTnI水平明显高于AP和NCCP组(P<0.01);三支病变组高于双、单支,左主干病变组和对照组(P<0.01);双、单支病变组比差异无统计学意义;左主干病变组高于双、单支病变组和对照组(P<0.01)。结论:血浆和肽素水平对AMI的诊断具有重要价值,其升高程度与冠状动脉病变严重程度具有良好的相关性。
Objective：To determine the plasma copeptin and troponin I concentration in patients with acute coronary syndrome,and to study the relationship with the extent of coronary artery lesion. Methods：One hundren and twenty patients with suspected coronary artery disease and coronary angiography were randomly divided into acute myocardial infarction（AMI,43 cases）、angina pectoris（AP,37 cases）and non cardiac chest pain（NCCP,40 cases）groups. According to the degree of coronary artery,three（28 cases）,double（23 cases）,single（21 cases）branch,left main（8 cases）lesions groups, control group of 40 cases were comfirmed. The plasma copeptin was determined using enzyme-linked immunosorbent assay and the troponin I level was detected using immune colloidal gold technique. Results：The plasma copeptin and troponin-I in the AMI group were obviously higher than those in the AP and NCCP groups（P0.01）. The plasma copeptin in the three-vessel group was remarkably higher than that in the one-or-two-vessel and left main groups（P0.01）. There was no significant difference between two-and one-vessel granps. The plasma copeptin level in the left main group was significantly higher than that two-and one-vessel groups（P0.01）. Conclusion：The plasma copeptin level is of very important to the diagnosis of AMI. The Elevated plasma copeptin has a good correlation with the severity of coronary artery disease.
出处
《汕头大学医学院学报》
2014年第3期156-158,174,共4页
Journal of Shantou University Medical College
