摘要
目的挖掘传统中医理论中的痰湿体质相关理论,总结近现代研究成果,系统阐述中医痰湿体质理论及其应用。探索痰湿体质基因表达特征,分析痰湿体质相关基因功能,阐发痰湿体质的内在分子机制。方法选用甲状腺癌BRAF基因组芯片检测技术,探索痰湿体质的基因表达特征。结果痰湿质甲状腺癌患者BRAF基因突变高表达。BRAF基因突变阳性的甲状腺癌患者中重度痰湿体质占94%(33/35)。结论痰湿体质是与多基因表达相关的体质状态,痰湿体质与平和体质相比,在基因表达上具有独特的基因表达谱,总体表现为代谢紊乱以及与免疫增强、炎症反应亢进、疾病发病、疾病抵抗基因相关的表达特征。
Objective By exploring the related theories of phlegm-dampness constitution in Traditional Chinese Medicine, we summarized the contemporary research achievement and systematically illustrated the theories of phlegm-dampness constitution and its application. We also aimed to investigate the gene expression characteristics of phlegm-dampness constitution, analyze the related gene function, and to unravel the molecule mechanisms. Methods The gene expression characteristics of phlegm-dampness constitution were investigated by using gene chip technology on BRAF gene of thyroid cancer. Results There is high expression of BRAF gene mutation in patients with phlegm-dampness constitution. Ninety-four percent （33/35） patients with thyroid cancer of BRAF gene mutation positivity were moderate to serere phlegm-dampness constitution. Conclusions There is high expression of BRAF gene mutation in patients with phlegm-dampness constitution. Phlegm-dampness constitution is one of the constitutions related to poly-gene expression, and has unique gene expression profile compared with the normal constitution. The main characteris-tics consist of metabolism disorder, expression of gene-related immuno-enhancement, hyperfunction of inflammatory response, and incidence and resistance of disease.
出处
《中国药物与临床》
CAS
2014年第10期1336-1337,共2页
Chinese Remedies & Clinics
基金
山西省中医药研究院院级课题(201105)
关键词
体质学说
甲状腺肿瘤
原癌基因蛋白质
B-RAF
Physical constitution theory
Thyroid neoplasms
Proto-oncogene proteins B-raf
