摘要
目的探讨慢性乙型肝炎患者不同的中医辨证分型是否引起淋巴细胞亚群和淋巴细胞VCS(V volume C conductivity S scatter)相应的变化。方法对符合纳入条件116病例分成三组,分别为肝郁脾虚型43例,湿热中阻型38例,瘀血阻络型35例,同时选健康体检人员为健康对照组48例。对各组进行ALT、WBC、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC、MLC-SD、MLS、MLS-SD的检测,分析各组上述指标间的相互关系。结果与健康对照组比较,肝郁脾虚型、湿热中阻型、瘀血阻络型三组的ALT、CD8+、MLV、MLV-SD、MLC-SD、MLS-SD均升高,差异有统计学意义(P<0.05),WBC、CD4+、CD4+/CD8+、MLC、MLS均下降,差异有统计学意义(P<0.05),与湿热中阻型比较,肝郁脾虚型的CD8+、MLV-SD、MLC-SD、MLS、MLS-SD差异有统计学意义(P<0.05),瘀血阻络型ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLS差异有统计学意义(P<0.05),与瘀血阻络型比较,ALT、CD4+、CD8+、CD4+/CD8+、MLV、MLV-SD、MLC-SD、MLC-SD、MLS、MLS-SD差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者证侯的变化,淋巴细胞的亚群表达及VCS参数的结果发生相应的变化,表明三者间存在密切的关系,可为中医辨证分型提供实验指标。
Objective To investigate the changes of T cell subsets VCS caused by different syndrome types in patients with Chronic Hepatitis B（CHB）. Methods A total of 116 samples were enrolled in the study, which were divided into3 groups： 43 CHB patients of liver depressions and spleen deficiency type, 38 of damp-heat type and 35 of blood stasis type. 48 healthy people were also included as normal control. ALT, WBC, CD4^＋, CD8^＋, CD4^＋/CD8^＋, MLV, MLV-SD,MLC, MLC-SD, MLS and MLS-SD of the 4 groups were tested and analyzed. Results ALT, CD8^＋, MLV, MLV-SD,MLC-SD and MLS-SD of CHB patients of liver depression and spleen deficiency type, damp-heat type and blood stasis type were significantly increased compared with normal group（P〈0.05）, however, WBC, CD4^＋, CD4^＋/CD8^＋, MLC and MLS were decreased apparently（P〈0.05）. CD8^＋, MLV-SD, MLC-SD, MLS and MLS-SD were significantly different between damp-heat type and liver depressions and spleen deficiency type（P〈0.05）. ALT, CD4^＋, CD8^＋, CD4^＋/CD8^＋,MLV, MLV-SD, MLC-SD and MLS were distinct between damp-heat type and blood stasis type（P〈0.05）. Conclusion T cell subsets and VCS parameters were varied in different CHB syndrome types, suggesting that correlations exited among T cell subsets, VCS parameters and syndrome type of CHB, which may provide useful information for Chinese medicine dialectical sub-typing of CHB.
出处
《中国现代医生》
2014年第30期58-60,63,共4页
China Modern Doctor
基金
浙江省教育厅科研项目(Y201121086)
关键词
中医辨证分型
慢性乙型肝炎
T淋巴细胞亚群
VCS参数
Chinese medicine dialectical sub-typing
Chronic hepatitis B
T cell subsets
VCS parameters
