摘要
目的:采用磁共振弥散张量成像(DTI)探讨丁基苯酞治疗对脑梗死患者梗死灶远隔部位继发性损害的影响。方法:60例急性脑梗死患者随机分为丁基苯酞组和对照组各30例。2组均给予抗血小板及基础治疗,丁基苯酞组加用丁基苯酞,于治疗前及治疗4周后行美国国立卫生研究院卒中量表(NIHSS)、改良Rankin评分(mRS)及DTI扫描,分别测量梗死灶、梗死同侧大脑脚及对侧相应区域的部分各向异性(FA)值。结果:治疗4周后,2组患者NIHSS和mRS评分均较治疗前降低(P<0.01),丁基苯酞组低于对照组(P<0.05);2组患者梗死灶及同侧大脑脚水平锥体束的FA值均较治疗前下降(P<0.01),丁基苯酞组的梗死灶、同侧大脑脚FA值均大于对照组(P<0.01)。结论:丁基苯酞可能通过减轻梗死后远隔损害而改善脑梗死患者的神经功能损害。
Objective：To study the effects of butylphthalide on secondary damage in area remote from cerebral infarction by diffusion tensor imaging （DTI）. Methods：Sixty patients with acute cerebral infarction were randomly divided into groups of butylphthalide and control （n=30 in each group）. Both groups were given basement treatment, and the butylphthalide group were given butylphthalide additionally. The 2 groups had DTI inspections respectively before and after treatment. Then the FA values of the infarctions, ipsilateral cerebral peduncle and corresponding contralateral regions were measured. The National Institutes of Health Stroke Scale （NIHSS） and modified Rankin Sclae （mRS） were used to evaluate the neurological function. Result：After 4-weeks treatment, the scores of NIHSS and mRS were decreased in two groups （ P〈0. 01）. However, the score of butylphthalide group was decreased significantly compared to control group （ P〈0.05）. Both the FA value of cerebral infarction lesions and corticospinal tract in the cerebral peduncle of the 2 groups were decreased after treatment, and the FA value of the infarction lesion and the ipsilateral cerebral peduncle of the butylphthalide group was significantly higher than that of control group （ P〈0.01）. Conclusion：Butylphthalide could relieve secondary damage in area remote from cerebral infarction, and then improve the prognosis of the patients of cerebral infarction.
出处
《神经损伤与功能重建》
2014年第5期391-394,共4页
Neural Injury and Functional Reconstruction
基金
广东省医学科研基金(No.A2011442)
关键词
脑梗死
继发损害
丁基苯酞
弥散张量成像
部分各向异性
cerebral infarction
secondary damage
butylphthalide
diffusion tensor imaging
farctional anisotropy
