摘要
目的研究女性Graves病患者血清Ghrelin与骨密度(BMD)的关系。方法 80例女性Graves病患者,合并骨质疏松(OP)组38例(OPl组)、骨含量正常组42例(OP2组),健康女性对照组25例(N组),测血清Ghrelin、FT3、FT4、TSH,并测量腰椎和股骨BMD。结果 (1)OPl、OP2组与N组比较,Ghrelin的水平差异有统计学意义(P<0.05);(2)OPl、OP2组Ghrelin水平无明显差异(P>0.05);(3)OPl、OP2组中Ghrelin与股骨BMD、椎骨BMD均无关(P>0.05)。结论合并OP患者血液中Ghrelin水平与股骨BMD、椎骨BMD间无相关性。
Objective To investigate the relationship between serum ghrelin level and bone mineral density （ BMD） in woman with Graves disease.Methods Eighty female patients with Graves disease were divided into group OP1 （ 38 cases, with osteoporosis） and group OP2 （42 cases, without osteoporosis）.Twenty-five healthy female people without Graves disease and osteoporosis were chosen as control group （ group N）.The serum levels of ghrelin, FT3, FT4, and TSH in all groups were detected.BMD of the lumbar vertebrae and the femur was determined using dual-energy X-ray absorptiometry.The correlation between ghrelin and BMD was analyzed.Result The serum levels ghrelin in group OP1 and group OP2 were significantly different with those in group N （ P〈0.05） .But no difference of the serum levels of ghrelin between group OP1 and group OP2 was observed （ P〉0.05 ） .The serum ghrelin level in group OP1 and group OP2 showed no correlation with BMD of the lumbar vertebrae and the femur （ P〉0.05） .Conclusion The serum ghrelin level in woman with Graves disease is not correlated with BMD of the lumbar vertebrae and the femur.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2014年第9期1059-1061,共3页
Chinese Journal of Osteoporosis
