摘要
目的探讨乌司他丁对心肺复苏后心肌功能障碍的保护作用。方法将成人心肺复苏自主循环恢复后的患者33例随机分为对照组(16例)按常规治疗,治疗组(17例)在常规心肺复苏综合治疗基础上加用乌司他丁20万单位静脉推注,每12 h推注1次,5 d为1个疗程。记录治疗前及治疗后12、24、72 h患者的血乳酸、心肌肌钙蛋白(c Tn I)及B型利钠肽(BNP)水平并计算12、24、72 h患者的血乳酸清除率。结果乌司他丁治疗组患者c Tn I,治疗后72h较对照组差异有统计学意义(P<0.05),BNP高峰(24 h)明显下降(P<0.05)。24、72 h乳酸清除率升高(P<0.05),组织灌注改善,住院天数缩短,病死率下降(P<0.05)。结论乌司他丁能改善心肺复苏术后患者的组织灌注、对心肌功能障碍有一定保护作用,对该类患者预后有积极影响。
Objective to investigate the protective effects of ulinastatin on myocardialdysfunction after cardiopulmonary resuscitation . Methods The adult cardiopulmonary resuscitation （ CPR） of spontaneous circulation recovery after 33 patients were randomly divided into control group（16 cases） by conventional treatment,the treatment group（17 cases） based on conventional cardiopulmonary resusci-tation（CPR） comprehensive treatment combined with ulinastatin 200000 units of intravenous injection,once every 12 h push note 1,5 d for a course of treatment.Recorded before and after treatment for 12,24,72 h of the patient＇s blood lactic acid,myocardial troponin（cT-nI） and b-type natriuretic peptide（BNP） levels and calculate the 12,24,72 h of the patient＇s blood lactate clearance rate.Results Ulinastatin treatment group patients cTnI ,72 h after treatment than the control group was statistically significant difference （ P〈0 .05 ） , the peak of the BNP（24 h） significantly decreased（P〈0.05）.24,72 h increased lactate clearance rate（P〈0.05）,improve tissue perfusion,shorten hospitalization days,the case fatality rate decreased（P〈0.05）.Conclusion Ulinastatin can improve cardiopulmo-nary resuscitation tissue perfusion in patients with myocardial dysfunction ,have certain protection effect ,positive impact on theprognosis of the patients with .
出处
《安徽医药》
CAS
2014年第12期2373-2375,共3页
Anhui Medical and Pharmaceutical Journal
