摘要
动物的肠道完整性在营养、代谢和机体内环境稳定中起着非常重要的作用,是机体抵御内源性和外源性有害物质的第一道屏障。肠上皮细胞的完整性是保障肠道功能的生理基础,肠上皮受损会影响营养物质的吸收,从而降低生产性能和影响动物的健康。N-乙酰半胱氨酸(NAC)是L-半胱氨酸与还原型谷胱甘肽(GSH)的前体物质,NAC的生理功能和应用效果在很大程度上与维持细胞内的GSH水平有关。饲粮中添加NAC可以缓解脂多糖应激引起的肠黏膜损伤、乙酸刺激引起的结肠炎及改善小肠吸收功能,这些与NAC促进表皮生长因子的生成、抗黏膜细胞凋亡和促进紧密连接蛋白表达有关。本文就NAC对猪肠道功能的保护作用相关研究作一综述。
The intestinal integrity plays an essential role in nutrition, metabolism, and whole-body homeostasis. The gastrointestinal tract is important as the first defense of the body against bacteria-derived endogenous and exogenous harmful agents. The integrity of the intestinal epithelium ensures its normal physiological functions. In contrast, any damage to the mucosal epithelium can impair the absorption of nutrients, thereby reducing the growth performance and compromising the health of animals. N-acetylcysteine （NAC） is a thiol donor and a precursor of L-cysteine and reduced glutathione. The physiologic functions and therapeutic effects of NAC are largely associated with maintaining the levels of intracellular glutathione （ GSH）. Dietary supplementation with NAC alleviates the mucosal damage and improves the absorptive function of the small intestine in li- popolysaccharide-challenged piglets. In addition, NAC supplementation could alleviate the mucosal damage and restore the colon function of acetic acid-challenged piglets. The underlying mechanisms of NAC＇ s action mainly include elevating biogenesis of epidermal growth factor, enhancing capacity of anti-apoptosis and increasing expression of fight junction proteins. This paper reviewed research advances of NAC＇ s action on porcine intestinal functions.
出处
《动物营养学报》
CAS
CSCD
北大核心
2014年第10期3064-3070,共7页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家973计划课题(2012CB126305)
国家自然科学基金项目(31372319)
