摘要
目的：观察止痛化癥胶囊在曲普瑞林治疗子宫腺肌病中的增效作用。方法：92例子宫腺肌病患者随机分为对照组30例、中西医结合I组30例、中西医结合II组32例。对照组：在月经的第1~5天内肌注曲普瑞林3.75 mg,每4周1次,3次后停止肌注;肌注结束4周后开始服用止痛化胶囊安慰剂,1次5粒,1日3次,服用12周。中西医结合I组：在月经的第1~5天内曲普瑞林肌注3.75 mg,4周1次,3次后停止肌注;4周后开始服用止痛化癥胶囊,1次5粒,1日3次,服用12周;中西医结合II组：在月经的第1~5天内曲普瑞林肌注3.75 mg,4周1次,3次后停止肌注;同时口服止痛化癥胶囊,1次5粒,1日3次,服用24周。结果：对照组、中西医结合I组、中西医结合II组临床显效率分别为83.3%、90.0%、93.8%,3组总有效率均为100.0%。治疗12周后3组子宫体积均明显缩小,血清CA125、痛经评分均明显下降（P〈0.05）。治疗24周后对照组复发10例,手术切除3例,其他两组各1例复发,中西医结合I组子宫切除1例,血清CA125、痛经评分均无明显升高。结论：止痛化癥胶囊能有效增强曲普瑞林治疗子宫腺肌病的疗效,值得临床进一步观察和研究,对其治疗的机理和机制有待于进一步深入探讨。
Objective： To observe the reinforcement effect of Zhitonghuazheng capsule on triptorelin in treatment of adenomyosis. Methods： A total of 92 patients were collected and randomly divided into control group （30 patients）, treatment I group （30 patients） and treatment Ⅱ group （32 patients） . The patients in control group were treated by transmuscular injection of triptorelin （3.75 nag） from the first day to the fifth day of menstrual cycle for three times, once every four weeks, on the fourth week after end of transmuscular injection, placebo was used for 12 weeks, five pills a time, three times a day ; the patients in treatment I group were treated by transmuscular injection of triptorelin （3.75 rag） from the first day to the fifth day of menstrual cycle for three times, once every four weeks, on the fourth week after end of transmuscular injection, Zhitonghuazheng capsule was used for 12 weeks, five pills a time, three times a day; the patients in treatment 11 group were treated by transmuseular injection of triptorelin （3.75 mg） from the first day to the fifth day of menstrual cycle for three times, once every four weeks, at the same time, Zhitonghuazheng capsule was used for 24 weeks, five pills a time, three times a day. Results： The clinical obvious effective rates in control group, treatment I group and treatment Ⅱ group were 83.3%, 90.0% and 93.8%, respectively, the total effective rates in the three groups were all 100. 0%. After 12 weeks, uterine volumes in the three groups decreased, serum CAI25 levels and dysmenorrhoeal scores in the three groups decreased significantly （ P 〈 0. 05 ） . After 24 weeks, 10 patients in control group recurred, 3 patients underwent operation; one patient in treatment I group and one patient in treatment Ⅱ group recurred respectively, the patient in treatment Ⅰ group underwent operation ; serum CA125 levels and dysmenorrhoeal scores didni increase significantly. Conclusion： Zhitonghuazheng capsule can enhance curative effect of tri
出处
《中国妇幼保健》
CAS
北大核心
2014年第30期4892-4894,共3页
Maternal and Child Health Care of China
基金
上海市卫生局中医药科研基金课题〔2010L101A〕
