摘要
目的分析不同时机肠内营养(EN)对重症急性胰腺炎(SAP)患者肠源性感染的影响。方法选取2010年5月-2012年5月收治的180例SAP患者,将其随机分为A、B、C 3组,每组各60例,分别在入院第2、4、6天实施肠内营养,比较3组患者各时期生理指标变化、肠源性感染及不良反应发生率,所有数据采用SPSS13.0进行统计分析。结果 A组出现2例肠源性感染,感染率3.3%,B、C组各出现5例、9例肠源性感染,感染率分别为8.3%、15.0%;A组入院第5天后C-反应蛋白、白细胞及内毒素含量下降,于第9天时分别降至(54.9±13.9)mg/L、(10.2±1.1)×109/L及(0.29±0.07)EU/L,下降程度显著优于B、C组,差异有统计学意义(P<0.05);3组患者各出现4例不良反应,发生率均为6.7%,不良反应发生率差异无统计学意义。结论 SAP患者入院第2天内给予肠内营养可有效降低炎症反应程度,预防肠源性感染的发生发展,是一种高效、可靠的SAP治疗手段。
OBJECTIVE To analyze the effect of enteral nutrition （EN ） on patients intestinal infection in severe acute pancreatitis （SAP） in different time .METHODS Totally 180 patients with SAP admitted from 2010 May to 2012 May were randomly divided into A ,B ,C group ,and each group has 60 patients .Enteral nutrition was given to the patients in the 1st ,4th and 6th day after admission respectively .And the physical signs ,gut derived infection and incidence of adverse reaction of these patients in different stage were compared .All the data were analyzed by SPSS13 .0 .RESULTS Group A occurred 2 cases of enterogenous infection with the infection rate of 3 .3% ,compared with 5 cases in group B（8 .3% ） and 9 cases in group C（15% ） ,respectively .The decrease of C reactive protein ,white blood cell and endotoxin were observed at the 5th day in group A ,and those three indexes declined to （54 .9 ± 13 .9）mg/L ,（10 .2 ± 1 .1）× 10^9/L and （0 .29 ± 0 .07）EU/L in the 9th day ,which decreased significantly compared to group B and C .The differences had significance .（P〈0 .05） .In each group occurred 4 cases of adverse reaction with the incidence of 6 .7% .The differences of adverse reaction incidence in the 3 groups were no significance .CONCLUSION Enteral nutrition given to the SAP patients who admitted to hospital for 2 days can effectively reduce the degree of inflammatory reaction and precaution the occurrence and development of enterogenic infection .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第20期5082-5083,5099,共3页
Chinese Journal of Nosocomiology
基金
河南省教育厅自然科学基金资助项目(2008B3600016)
关键词
肠内营养
不同时机
重症急性胰腺炎
肠源性感染
Enteral nutrition
Different time
Severe acute pancreatitis
Enterogenic infection
