摘要
鉴于肿瘤基础研究与临床研究长期脱节所致基础研究成果难以及时有效地转化为临床应用,近年以肿瘤转化医学理念为纽带的、加强并加快临床问题与基础成果双向转化的新思路逐渐成为业界共识.随着现代分子生物学和细胞生物学技术的迅猛发展,高通量深度测序、表观遗传学及微环境调节已在探索肿瘤标志物、阐析肿瘤发生发展机制中显示出强大的生命力.笔者拟简介及展望以临床问题或临床样本检测为出发点的深度测序、表观遗传学及微环境在当前肿瘤研究中的作用及应用.
In view of the imbalance between basic research and clinical research in cancer,and the failure of timely and effective translation from basic achievement to clinical application,new insights to strengthen and accelerate the bidirectional translation between clinical issues and basic achievement have being widely accepted,with the definition of Translational Medicine as a link.With the rapid development of modern molecular biology and cell biology techniques,the strong power of high-throughput deep sequencing,epigenetics,and microenvironment research on exploring cancer biomarkers and interpreting the mechanisms of carcinogenesis and progression,has being taken seriously.Here,we will illuminate the role and further application of deep sequencing,epigenetics,and microenvironment based on analysis from clinical issues or samples in the current cancer research.
出处
《中国医师杂志》
CAS
2014年第9期1153-1155,共3页
Journal of Chinese Physician
关键词
肿瘤/遗传学
生物转化
分子生物学
述评
Neoplasms/genetics
Biotransformation
Molecular biology
Editorial
