期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人类组织肽释放酶在卵巢癌中的表达及意义 被引量：4

Expression and significance of human tissue kallikrein in ovarian cancer
原文传递
导出
摘要 人组织激肽释放酶（KLK）基因家族由15个高度保守的丝氨酸蛋白酶组成，是人类基因组中最大的不间断排列的蛋白酶基因簇。许多 KLK 家族成员有望成为肿瘤诊断和预后的标志物。研究发现卵巢癌组织 KLK2-11、KLK13-15均异常表达，多种 KLK 有潜在的诊断和预后价值。 The human tissue kallikrein（KLK）gene family consists of 15 highly conservative serine proteases,which is the largest uninterrupted cluster of protease genes in the human genome. Several members of the family are expected to be markers for tumor diagnosis and prognosis. Studies find that the expressions of KLK2-11 and KLK13-15 are abnormal,and the majority of KLKs have potential diagnostic and prognostic values.
作者 褚芳波 陈英剑 胡成进
机构地区 辽宁医学院研究生学院 济南军区总医院实验诊断科
出处 《国际肿瘤学杂志》 CAS 2014年第8期608-611,共4页 Journal of International Oncology
关键词 卵巢肿瘤 肿瘤标记 生物学 人类组织激肽释放酶 Ovarian neoplasms Tumor markers, biological Human tissue kallikrein
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J].CA Cancer J Clin.2013, 63(1):11-30. 被引量：1
  • 2Dong Y, Stephens C, Walpole C, et al. Paclitaxel resistance and multicellular spheroid formation are induced by kallikreinrelated peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment[J]. PLoS One, 2013, 8(2):e57056. 被引量：1
  • 3Dorn J, Maqdolen V, Gkazepis A, et al. Circulating biomarker t8 kallikreinrelated peptidase KLK5 impacts ovarian cancer patients′ survival[J].Ann Oncol.2011, 22(8):1783-1790. 被引量：1
  • 4Bayani J, Diamandis EP. The physiology and pathobiology of human kallikrein related peptidase 6(KLK6)[J]. Clin Chen Lab Med, 2011, 50(2):211-233. 被引量：1
  • 5El Sherbini MA, Sallam MM, Shaban EA, et al. Diagnostic value of serum kallikreinrelated peptidases 6 and 10 versus CA125 in ovarian cancer[J].Int J Gynaecol Cancer.2011, 21(4):625-632. 被引量：1
  • 6Dorn J, Gkazepis A, Kotzsch M, et al. Clinical value of protein expression of kallikreinrelated peptidase 7 (KLK7) in ovarian cancer[J]. Biol Chem, 2014, 395(1):95-107. 被引量：1
  • 7Kountourakis P, Psyrri A, Scorilas A, et al. Expression and prognostic significance of kallikreinrelated peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis[J]. Thromb Haemost, 2009, 101(3): 541-546. 被引量：1
  • 8文彦.卵巢上皮性癌患者肿瘤组织和血清KLK8的表达及临床意义[J].大家健康（学术版）,2012(18):6-8. 被引量：1
  • 9Yousef GM, Kyriakopeulou LG, Seorils A, et al. Quantitative expression of the human kallikrein gene 9(KLK9) in ovarian cancer:a new independent and favorable prognostic marker[J]. Cancer Res, 2001, 61(21):7811-7818. 被引量：1
  • 10王翠翠,张晓霞,王丽娜,许淑芬,欧健,田海涵.卵巢癌患者血清人激肽释放酶10的检测及其临床意义[J].吉林大学学报（医学版）,2010,36(3):540-542. 被引量：8

二级参考文献32

  • 1井明艳,孙建义.激肽释放酶的研究进展[J].中国抗生素杂志,2005,30(3):187-192. 被引量：4
  • 2Southan C. A genomic perspective on human proteases as drug targets[J]. Drug Discov Today, 2001, 6(13) :681. 被引量：1
  • 3Yousef GM, Scorilas A, Jung K,et al. Molecular cloning of the human kallikrein 15 gene ( KLKI5 ) : up-regulation in prostate cancer[ J]. J Biol Chem,2001,276(1) :53. 被引量：1
  • 4Stephan C, Yousef GM, Scorilas A,et al. Quantitative analysis of kallikrein 15 gene expression in prostate tissue [J]. J Urol,2003,169(1) :361. 被引量：1
  • 5Juretzka MM,Barakat RR,Chi DS,et al. CA125 level as a predictor of progression-free survival and overall survival in ovarian cancer patients with surgically defined disease status prior to the initiation of intraperitoneal consolidation therapy[J]. Gynecol Oncol,2006,104( 1 ) : 176. 被引量：1
  • 6Yousef GM, Scorilas A, Magklara A,et al. The androgen- regulated gene human kallikrein 15 ( KLK15 ) is an independent and favourable prognostic marker for breast cancer [J]. Cancer, 2002,87(11):1 294. 被引量：1
  • 7Diamandis EP, Yousef GM, Clements J, et al. New nomenclature for the human tissue kallikrein gene family [J]. Clin Chem, 2000, 46 (11): 1855-1858. 被引量：1
  • 8Luo LY, Katsaros D, Scorilas A, et al. Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma[J]. ClinCaneer Res, 2001, 7 (8), 2372-2379. 被引量：1
  • 9Rosen DG, Wang L, Atkinson JN, et al. Potential markers that complement of CA125 in epithelial ovarian cancer[J]. Gynecol Oncol, 2005, 99 (22):267-277. 被引量：1
  • 10Jacobs J, Menon U. Progress and challenges in screening for early detection of ovarian cancer[J]. Mol Cell Proteomics, 2004, 3 (4): 355-366. 被引量：1

共引文献10

同被引文献34

引证文献4

二级引证文献13

国际肿瘤学杂志
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部