摘要
川崎病在发达国家已经取代风湿热成为儿童最常见的后天性心脏病，但其病因仍然不明。川崎病动物模型可以帮助我们更好地研究川崎病和制定新的有效的治疗方案。在已有的动物模型中，单次腹腔注射干酪乳杆菌细胞壁萃取物诱导小鼠冠状动脉炎模型较为成熟。该文就干酪乳杆菌细胞壁萃取物诱导的小鼠川崎病模型的建立及其相关研究进展作一综述。
Kawasaki disease has replaced rheumatic fever as the most common acquired heart disease in childhood,but its etiology remains unknown. The development and analyses of animal models will help us under-stand KD and find new and effective therapeutic strategies for it. Among these existing animal models, mouse modelof coronary artery inflammation induced by a single intraperitoneal injection of lactobacillus casei cell wall extract is a relatively mature model. In this review,we present an overview of how this model established and some progress in research of the mouse model.
出处
《国际儿科学杂志》
2014年第5期519-523,共5页
International Journal of Pediatrics
基金
国家自然科学基金资助项目（81270177）
关键词
川崎病
冠状动脉炎
动物模型
干酪乳杆菌细胞壁萃取物
Kawasaki disease
Coronary arteritis
Animal models
Lactobacillus casei cell wall extract
