摘要
目的:优选水包油型乳膏基质处方及其制备工艺。方法:以基质的性状外观、稳定性、保湿性为考察指标,筛选水包油型乳膏基质处方;以乳化时间、搅拌速度、乳化温度、乳化方法为考察因素,采用正交试验优选水包油型乳膏基质的制备工艺。结果:优良的基质处方及制备工艺为:十六醇4.5 g、十八醇4.5 g、二甲基硅油20.0g、霍霍巴油2.0g、单硬脂酸甘油酯7.4 g、十二烷基硫酸钠2.0g、甘油10.0g、山梨酸0.1 g、水加至100 g;搅拌速度350 r·min-1、搅拌温度80℃、搅拌15 min、水相加入油相法。结论:优选得到的基质洁白、细腻、有光泽、稠度适宜、易涂布、稳定性好,基质制备工艺稳定可行。
OBJECTIVE To optimize the preparation techniques through screening good quality of oil-in-water type cream matrix.METHODS The preparation technology of cream matrix was studied using orthogonal design,taking the external appearance forms,the stability and moisturizing effect of the creams as the investigation index.The 4 kinds of main influencing factors（emulsion time,stirring speed,emulsion temperature and emulsion method）were screened.RESULTS The best cream matrix prescription and preparation technology were as follows：cetyl alcohol 4.5 g,stearyl alcohol 4.5 g,dimethicone 20 g,jojoba oil 2 g,glyceryl monostearate 7.4 g,sodium lauryl sulfate 2 g,glycerin 10 g,sorbic acid 0.1 g,adding water to 100 g;stirring speed 350 r·min-1,stirring temperature 80℃,mixing 15 min,water phase by adding oil phase.CONCLUSION The high quality of cream matrix has a spotlessly white,luster,easy to daub and stable quality,the preparation technology is reliable and practical.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第18期1562-1566,共5页
Chinese Journal of Hospital Pharmacy
关键词
水包油型
乳膏基质
制备工艺
正交试验
oil-in-water type
cream matrix
preparation technology
orthogonal design
