摘要
本文扼要概述了当前可运用于中药新药筛选的高通量筛选、生物芯片、分子生物色谱、高内涵筛选、网络药理学、蛋白质组学和计算机辅助虚拟筛选等新技术和新方法,并结合本单位研究开发实践,基于调脂代谢机理,将计算机辅助虚拟筛选技术,如分子对接、药效团、分子相似度等应用到中药新药的筛选、处方优化和作用机理研究中,为中药新药筛选研发工作提供借鉴。
This article focused on summarization of the available new screening technology for traditional Chinese medicine （TCM） new drug, including high throughput screening （HTS）, biological chip, molecular biological chro-matography, high content screening （HCS）, network pharmacology, proteomics, and computer-aided drug design （CADD）. And in this review, one example that we applied CADD technology （such as molecular docking, pharma-cophore and molecular similarity） in lipid-lowering TCM new drug development was given. Based on the mechanism of lipid metabolism, CADD technology provided a good method on the prescription optimization and mechanism study. In addition, TCM new drug development proposal which displayed in this paper may provide a useful strategy for screening of TCM new drug.
出处
《世界科学技术-中医药现代化》
北大核心
2014年第8期1696-1702,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
广东省科技厅战略性新兴产业核心技术攻关项目(2012A080800003):调血脂创新药物产业化关键技术及临床研究
负责人:谭登平
涂瑶生
关键词
中药新药
筛选
新技术
实践
TCM new drug
screening
new technology
practice
