摘要
目的:慢性心力衰竭(CHF)患者终末期阶段常发生左室(LV)重塑和心脏性恶病质,有研究称Ghrelin可能对CHFLV功能和能量代谢产生保护作用。本文旨在探讨Ghrelin对CHF大鼠LV功能紊乱和心源性恶病质的作用。方法:建立左冠状动脉结扎术和假手术组,手术后4周,给予大鼠Ghrelin或生理盐水3周。用超声心动图和心脏导管术监测结果。结果:与给予安慰剂组相比,用Ghrelin治疗的CHF和假手术组,血浆GH和胰岛素样生长因子1明显升高(t=1.49,t=0.71,P<0.05)。与Sham-Placebo组相比,CHF-Placebo组大鼠体重明显减轻(t=2.18,P<0.05)。然而与CHF-Placebo组相比,CHF-Ghrelin组大鼠,体重(t=3.89,P<0.05),心输出量(t=3.28,P<0.05),LV dP/dtmax(t=3.90,P<0.05)明显增加。Ghrelin增加了CHF大鼠心脏舒张压,抑制LV扩大,增加LV缩短分数。结论:长期注射Ghrelin可改善CHF大鼠LV功能紊乱,减缓LV重构和心脏性恶病质的发展,有望为CHF的治疗提供新的途径和方法。
Objective： Chronic heart failure （CHF） patients in end-stage often appear left ventricular （LV） remodeling and cardiac cachexia. It is reported that ghrelin had protecting effect on CHF LV function and energy metabolism. The purpose of this study is to explore the effects of ghrelin on LV dysfunction and cardiac cachexia in CHF rats, Methods： Ligation of the left coronary artery or sham operation was performed; 4 weeks after surgery, ghrelin （100 mg/kg SC BID） or saline was administered for 3 weeks. Echocardiography and cardiac catheterization were performed. Results： Serum GH and insulin-like growth factor-1 were significantly higher in both CHF and sham rats treated with ghrelin than in those given placebo （P〈0.05 for both）. CHF rats given placebo showed an impaired increase in body weight compared with sham rats given placebo （P〈0.05）. CHF rats treated with ghrelin, however, showed a significantly greater increase in body weight than those given placebo （ 110 % versus 13 %, P〈0.05）. They showed significantly higher cardiac output （P〈0. 05） and LV dP/dtmax （P〈0.05） than CHF rats given placebo. Ghrelin increased diastolic thickness of the noninfarcted posterior wall, inhibited LV enlargement, and increased LV fractional shortening in CHF rats. Conclusion： Chronic administration of ghrelin can improve LV dysfunction and slow down the development of LV remodeling and cardiac cachexia in rats with CHF. Ghrelin is expected to become a new method for the treatment of CHF.
出处
《现代生物医学进展》
CAS
2014年第31期6022-6027,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(31071014
81100260
81270460
81300281)
山东省医药卫生科技发展计划项目(2013WS0263)
青岛市科技局项目(13-1-4-170-jch)
