摘要
动脉粥样硬化(As)斑块破裂是导致急性心脑血管事件发生的首要原因。既往对斑块破裂的基础研究多集中于细胞和分子水平,从表观遗传学角度阐述的研究较少。DNA甲基化作为表观遗传学修饰的主要方式之一,可在不改变基因核苷酸序列的情况下影响基因的表达。综合目前研究来看,炎症反应在斑块破裂过程中起关键性作用,而DNA甲基化对炎症反应又起重要的调控作用。因此,改变DNA甲基化状态来调控炎症反应干预As斑块稳定性,有望成为防治As等心脑血管疾病的有效途径之一。本文主要围绕与As炎症反应密切相关的几种炎症免疫细胞及炎症因子等方面,对近年来DNA甲基化调控炎症反应干预As斑块稳定性的研究进展作一综述。
The rupture of atherosclerotic plaque is the leading cause of the acute cardiovascular and cerebrovascular diseases. Although there are many basis researchs on the rupture of plaque concentrated on the cellular and molecular level, while less on the epigenetics. DNA methylation, as the main way of epigenetics, can regulate the expression of the genome without changing the nucleotide squence. According to the current researches, inflammation plays a key role in the process of rupture, while DNA methylation plays an important role in the regulation of inflammation. Therefore, to change the status of DNA methylation to regulate the inflammatory may be one important way to cure the diseases. The intervention of DNA methylation regulating the inflammation on the plaque stability will be reviewed in this paper, from several inflammatory cells and cytokines closely related to the infammation in As.
出处
《现代生物医学进展》
CAS
2014年第32期6383-6386,共4页
Progress in Modern Biomedicine
基金
北京市自然科学基金课题(7133233)
北京市自然科学基金项目(7142037)
北京市科技新星计划课题(Z131107000413026)
国家自然科学基金项目(81303086)
