摘要
案导致骨髓抑制的疗效及安全性。方法选取2011年1月至2012年6月行GP方案化疗的119例恶性肿瘤患者,分为对照组（n=55）和治疗组（n=64）,两组均给予GP方案（吉西他滨1g/m2,d1、d8;顺铂20mg/m2,d1~d8;21天为1周期）,治疗组于化疗前1~2天开始口服复方阿胶浆,20ml/次,每日3次,直至化疗结束后1周。比较两组化疗期间使用重组人白细胞介素-11（rhIL-11）和重组人粒细胞集落刺激因子（rhGCSF）的剂量,以及第1、2个周期化疗前的血小板、白细胞计数及化疗后的血小板、白细胞计数最低值和因骨髓抑制导致的化疗推迟率,同时化疗2个周期后采用实体瘤疗效评价标准（RECIST）1.1版评价近期疗效。结果治疗组的rhIL-11和rhGCSF用量均低于对照组（P〈0.05）;两组第1、2个周期化疗前的血小板、白细胞计数的差异无统计学意义（P〉0.05）;治疗组第1、2个周期化疗后的血小板计数最低值高于对照组（P〈0.05）,但两组第1、2个周期化疗后的白细胞计数最低值的差异无统计学意义（P〉0.05）。治疗组按时完成107个化疗周期,推迟21个;而对照组按时完成75个化疗周期,推迟35个;治疗组的化疗推迟率低于对照组（16.2%vs.32.1%,P〈0.05）。对照组的有效率和临床控制率分别为49.09%和85.45%,与治疗组的43.75%和79.69%比较,差异无统计学意义（P〉0.05）。治疗组服用复方阿胶浆期间未见任何明确相关的不适感及副作用。结论复方阿胶浆可改善GP方案化疗导致的骨髓抑制,有效提高外周血中血小板水平,对化疗的近期疗效无负面影响,但其长期效果仍需进一步观察。
Objective To investigate the effect of donkey-hide gelatin mixture on myelosuppression induced by gemcitabine and cisplatin （GP） chemotherapy. Methods According to the treatment, 119 patients with malignant tumor from 2011 January to 2012 June were assigned into treatment group（ n= 64） and control group（ n = 55）. Both groups received GP regime （gemcitabine, 1g/ m2, dI , d8 ; cisplatin, 20mg/m2, d1 -d8 ; 21 days was a cycle） for chemotherapy. Only the treatment group received donkey-hide gelat- in mixture （20ml per time, rid） from 1-2 days before chemotherapy to one week after the end of chemotherapy. The usage of chemo- therapy of interleukin-11 （rhIL-11） and recombinant human granulocyte colony stimulating factor （rhG-CSF） during chemotherapy were compared between two groups. The white cell counts and platelet counts before the Ist and 2no cycle of chemotherapy, minimum values of white cell count and platelet count after 1st and 2nd cycle of chemotherapy and postponed rates caused by bone marrow suppres- sion were recorded between groups. The Response Evaluation Criteria in Solid Tumors （RECIST） criteria （ version 1.1 ） was employed to evaluate the short-term effect after chemotherapy for 2 cycles. Results The usage of both rhIL-11 and rhG-CSF in treatment group were lower than those in control group （P〈0. 05）. No statistically significant difference was observed between both groups on platelet counts and blood cell counts before the 1st and 2nd cycle of chemotherapy （P〉0.05）. The minimum values of platelet count were higher in treatment group versus control group after the 1st and 2nd cycle of chemotherapy （P〈0. 05 ）, but the minimum values of blood cellcounts were similar between groups （ P〉0. 05）. The treatment group completed 107 cycles of chemotherapy on schedule, while the con- trol group completed 75 cycles of chemotherapy on schedule. The postponed rates of treatment group was lower than that of control group （ 16. 2% vs. 32. 1%, P〈0. 05）.
出处
《临床肿瘤学杂志》
CAS
2014年第8期739-742,共4页
Chinese Clinical Oncology
关键词
吉西他滨
顺铂
复方阿胶浆
骨髓抑制
Gemcitabine
Cisplatin
Donkey-hide gelatin mixture
Bone marrow suppression
