摘要
目的 探讨GB病毒C(GBV -C)的致病性 ,以及混合感染GBV -C后对慢性乙型肝炎及慢性丙型肝炎预后的影响。方法 对我国河南省某市 95例慢性乙型肝炎患者及某农村 80例慢性丙型肝炎患者进行了现况调查 ,并于其后 6个月及 2 0个月进行前瞻性队列研究。结果 GBV -C混合感染率在慢性乙型肝炎患者中为 2 0 0 %～ 2 5 0 % ,在慢性丙型肝炎患者中为 2 8 3%～ 33 5 %。混合感染GBV -C后 ,对于慢性肝炎患者的肝功能水平未产生显著影响。结论 表明在慢性乙型肝炎和慢性丙型肝炎患者中 ,未发现混合感染GBV -C明显加重肝损伤 。
Objective To study the pathogenicity of GB virus C(GBV-C),and effect of coinfection with GBV-C on hepatitis B and C.Methods GBV-C was determined in sera of 95 patients who were diagnosed as chronic hepatitis B and 80 patients of hepatitis C.Cohort study for 6,20 months was conducted.Results The rate of HBV and GBV-C mixed infection was 20 0%～25 0% and rate of HCV and GBV-C mixed infection was 28 3%～33 5%.Serum ALT,AST,TBil,etc were compared between with and without GBV-C infecton.No significant difference was found between the two groups.GBV-C did not effect the clearance of HBV and HCV.Conclusion The study suggested that mixed infection of GBV-C did not lead to significant effect on patients with chronic hepatitis B and hepatitis C.It was lack of pathogenicity that GBV-C existed in liver disease.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第8期911-913,共3页
Chinese Journal of Public Health
基金
国家自然科学基金资助项目 批准号 :39870 695
