摘要
随着分子生物学技术的发展,应用DNA重组技术、抗体库技术及转基因技术对鼠源性单抗进行人源化改造,先后出现了嵌合抗体、互补决定区移植抗体和全人源抗体,它们从不同角度克服了鼠源性单抗临床应用的不足,为单克隆抗体在临床诊断及治疗中的应用带来了新的曙光,该文对单克隆抗体人源化技术的研究进展作一综述。
With the development of molecular biology, people can humanize mouse monoclonal antibody with DNA recombination, antibody library and transgenic technology which developed antibody techniques from chimeric and grafted antibody to fully human antibody. The humanized monoclonal anti-bodies overcome the clinical shortage of mouse monoclonal antibody from different angles, also bring a new dawn to the diagnosis and treatment of human disease. This article will summarize the progress on the hu-manization of mouse monoclonal antibody.
出处
《国际放射医学核医学杂志》
2014年第5期328-331,共4页
International Journal of Radiation Medicine and Nuclear Medicine
关键词
单克隆抗体
噬菌体展示
人源化抗体
嵌合抗体
CDR移植抗体
全人源单抗
Antibodies,monoclonal
Phage display
Humanized antibody
Chimeric antibody
Complementarity-determining region grafted antibody
Fully human antibody