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HLA-E基因多态性与乳腺癌发病风险相关性研究 被引量：5

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摘要 目的探讨人类白细胞抗原E(HLA-E)等位基因多态性与乳腺癌遗传易感性的相关性。方法选择经病理确诊的乳腺癌患者70例为乳腺癌组,选择健康女性60例为对照组,取两组外周静脉血4 mL,采用聚合酶链反应—序列特异性寡核苷酸探针杂交(PCR-SSOP)方法检测两组HLA-E等位基因多态性,分析HLA-E基因多态性与乳腺癌的相关性。结果两组均检出HLA-E等位基因E*0101及E*0103,乳腺癌组、对照组E*0101基因频率分别为54.29%(38/70)、81.67%(49/60),乳腺癌组E*0101基因频率低于对照组(P<0.05)。乳腺癌组、对照组E*0103基因频率分别为87.14%(61/70)、45%(27/60),乳腺癌组E*0103基因频率高于对照组(P<0.05)。Logistic分析示E*0103等位基因与乳腺癌的发生呈正相关。结论 HLA-E基因多态性与乳腺癌的发生有关,HLAE*0103等位基因可能与乳腺癌遗传易感性存在相关性。
作者 李红涛
机构地区 焦作市人民医院
出处 《山东医药》 CAS 2014年第22期45-46,共2页 Shandong Medical Journal
关键词 乳腺癌 HLA-E基因 多态性
分类号 R392 [医药卫生—免疫学]
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参考文献13

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共引文献9

同被引文献40

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山东医药
2014年 第22期

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