摘要
目的：探讨小G蛋白信号调制因子3基因（SGSM3）4碱基插入/缺失多态rs56228771与中国汉族人群结直肠癌遗传易感性之间的相关性。方法：采用非变性聚丙烯酰胺凝胶电泳方法检测339例汉族结直肠癌患者和319名健康人（对照组）的SGSM3 rs56228771多态性的分布频率,以非条件性logistic回归模型分别对年龄、性别、吸烟及饮酒状况进行校正后计算优势比（OR）及95%置信区间（CI）。结果：结直肠癌组SGSM3基因型（I/I、I/D、D/D）分布频率分别为2.36%、24.78%和72.86%,对照组分别为4.08%、33.86%和62.07%,2组的频率分布差异有统计学意义（P〈0.05）。携带SGSM3 I/I基因型的个体较携带D/D基因型的个体患结直肠癌的风险降低（OR=0.49；95%CI 0.20~1.21；P〈0.05）。等位基因分析表明,携带SGSM3 I基因的个体较携带 D 基因的个体患结直肠癌的风险降低（ OR =0.65；95%CI 0.49~0.87；P〈0.01）。结论：SGSM3 rs56228771位点多态性与中国汉族人群结直肠癌易感性具有相关性。
Objective：To explore the correlation of SGSM3 rs56228771 polymorphisms and susceptibility of colorectal cancer in Han people. Methods：The distribution frequencies of SGSM3 rs56228771 in 339 Han patients with colorectal cancer（ colorectal neoplasm group） and 319 healthy people were detected using non-denaturing PAGE. The odds ratio（ OR） and 95% confidence intervals（ CI） of age,sex,smoking and drinking status after adjustment were calculated using unconditional logistic regression analysis. Results：The frequencies of SGSM3 I/I,I/D and D/D genotypes in colorectal cancer group and control group were 2. 36%,24. 78% and 72. 86%, and 4. 08%,33. 86% and 62. 07%,respectively,the differences of whose were statistically significant（P〈0. 05）. The risk of colorectal cancer in cases with SGSM3 I/I genotype was lower than that in cases with D/D genotype（OR=0. 62,95%CI 0. 20 to 1. 21,P＆lt;0. 05）. The risk of colorectal cancer in cases with SGSM3 I gene was lower than that in cases with D gene（OR=0. 49,95%CI 0. 49 to 0. 87,P〈0. 01）. Conclusions：The SGSM3 rs56228771 polymorphism is directly related to the susceptibility of colorectal cancer in Han people.
出处
《蚌埠医学院学报》
CAS
2014年第9期1156-1158,共3页
Journal of Bengbu Medical College
