摘要
目的:探讨冠心病合并糖尿病与单纯冠心病的危险因素和临床特点的差异。方法 :1 926例行冠状动脉造影(coronary angiography,CAG)检查的个体确诊为冠心病的患者1 277例,分为冠心病无糖尿病组和冠心病合并糖尿病组,同时确诊非冠心病个体649例作为对照组。收集相关危险因素和临床资料。结果:3组总体比较,性别、年龄、体质指数(body mass index,BMI)、空腹血糖、载脂蛋白A、脂蛋白a、高血压、本次入院发病心脏彩超左心室射血分数、吸烟、每天吸烟量、饮酒及工作活动强度和平时锻炼频率在3组人群中的分布差异有统计学意义(P<0.05);冠心病无糖尿病组和冠心病合并糖尿病组相比,BMI、空腹血糖、载脂蛋白A和每天吸烟量差异有统计学意义(P<0.05);多因素Logistic回归分析结果表明,与阴性对照组相比,男性、年龄>60岁、高血压、吸烟等因素可增加单纯冠心病发病风险,同时年龄>60岁、BMI≥24、高水平总胆固醇和吸烟是冠心病合并糖尿病发生的高危因素;与单纯冠心病组相比,女性、BMI≥24、高水平甘油三酯可增加冠心病合并糖尿病的发生风险。结论:女性、BMI≥24、血脂水平异常和冠脉多支病变等因素可增加冠心病合并糖尿病的发生风险。应开展针对性的人群预防,加强冠心病合并糖尿病危险因素的综合防治,对提高冠心病合并糖尿病的生活质量和改善预后有着重要意义。
Objective：To explore the differences of risk factors and clinical characteristics between coronary artery disease （CAD） complicated with diabetes mellitus （DM） and CAD. Metbods：A total of 1 277 patients who were diagnosed with CAD by coronary angiography（CAG） from 1 926 patients were divided into the CAD without DM group and the CAD complicated with DM group. Meanwhile,649 patients with no CAD diagnosed from the 1 926 patients by CAG were considered as the control group. The clinical characteristics and the related risk factors of the subjects were collected. Results：Among the three groups, the distributions of the gender, age, BMI, fasting blood glucose （GLU）, apolipoprotein A （apoA）, lipoprotein a, hypertension, cardiac color ultrasound of LVEF （%）,smoking status,daily smoking,drinking status,the intensity of work and the usual frequency of exercise were significantly different （P 〈 0.05）. For the CAD with DM and without DM groups, BMI, GLU, apoA, daily smoking were significantly different （P 〈 0.05）. Multivariate Logistic regression analysis showed that, compared with the control group, male, age 〉 60 y, hypertension, smoking were associated with the increased risk of CAD. Meanwhile, male, age 〉 60 y, BMI ≥ 24 （kg/m2）, high levels of TC and smoking had a significantly increased risk of CAD with DM. Compared with the CAD without DM group, female, BMI ≥ 24 and high levels of TG were associated with the increased risks of CAD with DM. Conclusion：Female, BMI≥ 24,blood lipid abnormality and 3 lesions of coronary artery might be the risk factors for CAD with DM. Many measures should be carried out to release these risk factors and to improve the life quality of patients with CAD with DM and the prognosis of CAD with DM.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第9期1218-1223,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金青年项目(30901230
81300249)
关键词
冠心病
冠心病合并糖尿病
危险因素
coronary artery disease
coronary artery disease complicated with diabetes mellitus
risk factors
