摘要
目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)、红细胞沉降率(ESR)和白细胞(WBC)计数对肺结核(PTB)合并肺部感染诊断的差异性。方法检测临床确诊为活动性PTB合并肺部感染和未合并感染患者血PCT、CRP、ESR和WBC,采用SPSS 16.0软件对两组资料进行统计分析,MedCalc V12.7.7.0软件进行接受者操作特性(ROC)曲线分析,计算并比较各指标曲线下面积(AUC),确定最佳临界值。结果合并感染组血PCT、CRP、ESR和WBC均高于未合并感染组,差异有统计学意义(均P<0.01);4个指标诊断PTB合并肺部感染的AUC分别是0.89、0.75、0.74和0.72,PCT的AUC明显高于其他三个指标,差异有统计学意义(P<0.01);最佳临界值分别是0.29 ng/ml、15.00 mg/L、37.00 mm/h和7.86×109/L。结论血PCT、CRP、ESR和WBC对诊断PTB合并肺部感染均有一定价值,PCT优于其他3个指标。
Objective To investigate the differences among serum procalcitonin （PCT）, C-reactive protein （CRP）, erythrocyte sedimentation rate （ESR） and white blood cell count （WBC） in diagnosing pulmonary tuberculosis （PTB） complicated with pulmonary infection. Methods The levels of PCT, CRP, ESR and WBC were detected in active PTB patients complicated with pulmonary infection and patients without infection. The data was analyzed statistically by SPSS16.0 software. The receiver operating characteristic （ ROC ） curves and area under the curve （AUC） of each indicator were analyzed by MedCalc V12.7.7.0 software. AUC and the cut-off values were calculated and compared by ROC. Results Blood PCT, CRP, ESR and WBC level in PTB patients complicated with pulmona- ry infection were all significantly higher those without infection （ P 〈 0. 01 ）. The AUC of four indicators diagnosing PTB complicated with pulmonary infection were O. 89, 0. 75, 0. 74 and 0.72 respectively, and AUC of PCT was significantly higher than the other three indicators （P 〈0. 01 ）. The cut-off values of PCT, CRP, ESR and WBC were 0. 29 ng/ml, 15.00 mg/L, 37.00 mm/h and 7.86 × 10^9/L respectively. Conclusion Blood PCT, CRP, ESR and WBC level may be useful in the diagnosis of PTB complicated with pulmonary infection and PCT is better than the other three indicators.
出处
《临床肺科杂志》
2014年第11期2009-2011,共3页
Journal of Clinical Pulmonary Medicine
基金
湖南省科技厅项目(No 2013FJ3114)
