摘要
目的:探讨胃癌组织中Smad3、HER2、SPARC蛋白表达与其预后的关系。方法:选取2008年6月至2012年11月我院病理科确诊的61例患者的胃癌组织,采用免疫组织化学法检测Smad3、HER2、SPARC蛋白表达情况和logistic回归分析法对Smad3、HER2、SPARC蛋白表达与预后的关系进行分析,且另选相应癌旁组织10例作为对照。结果:胃癌组织中HER2蛋白表达阳性率高于癌旁组织,Smad3、SPARC阳性率低于癌旁组织(P<0.05);Smad3、HER2、SPARC蛋白表达与胃癌TMN分期、分化程度及淋巴结转移均有关(P<0.05);TNM分期、淋巴结转移、Smad3、SPARC及HER2表达均可作为宫颈癌独立预后预测因素。结论:Smad3、HER2、SPARC蛋白表达对胃癌远期治疗有意义,有望成为评价胃癌远期疗效的指标。
Objective：To discuss the relationship of the expression of protein Smad3, HER2, and SPARC in gastric cancer tissues with the prognosis. Methods： The gastric cancer tissues from sixty-one cases of patients diagnosed by the department of pathology in our hospital from June, 2008 to November, 2012 were selected. The expression of protein Smad3, HER2, SPARC was determined by immunohistochemical method and the relationship between the expression and the prognosis was analyzed by logistic regression analysis method. In addition, the tumor-adjacent tissues from other ten cases of patients were selected as a control. Results： The positive expression rate of HER2 in gastric cancer tissues was higher than that in tumor-adjacent tissues while that of Smad 3, SPARC was lower （P＆lt;0.05）. The expression of protein Smad3, HER2, SPARC was related to TMN staging of gastric cancer, differentiation degree and lymph node metastasis （P＆lt;0.05）. TNM staging, lymph node metastasis, the expression of Smad3, SPARC and HER2 can be used as independent prognostic factors of cervical cancer. Conclusion：The expression of Smad3, HER2, SPARC is meaningful for long-term treatment, and is expected to become an index for the evaluation of long-term efifcacy of gastric cancer.
出处
《上海医药》
CAS
2014年第19期50-52,共3页
Shanghai Medical & Pharmaceutical Journal
基金
江西省卫生厅2013年度科技计划项目(项目编号:20133204)
