摘要
目的观察甘露聚糖肽联合奈达铂胸腔内灌注治疗恶性胸腔积液的疗效。方法将94例恶性胸腔积液患者随机分为两组,观察组48例采用甘露聚糖肽+奈达铂胸腔内灌注,对照组46例单纯采用奈达铂灌注。治疗后观察两组的有效率及不良反应发生情况。结果观察组有效率(85.4%)高于对照组(69.6%)(P<0.05);观察组胃肠道反应、骨髓抑制及胸痛发生率分别为35.4%、22.9%和18.8%,与对照组比较明显降低,两组比较差异有统计学意义(P<0.05)。结论甘露聚糖肽联合奈达铂治疗恶性胸腔积液有效率高,不良反应少,值得临床推广。
Objective To observe the efficacy of mannatide injection and nedaplatin injected in thoracic cavity in the treatment of malignant pleural effusion. Methods Ninety-four patients with malignant pleural effusion were randomly divided into two groups. The observation group of 48 patients were given mannatide injection and nedaplatin,and con-trol group of 46 patients were given only nedaplatin. Effectiveness and adverse reactions were observed after treatment. Results The effective rate was 85.4% in observation group, hihger than that in control group （69.6%）（P〈0.05）; The incidence rates of gastrointestinal tract and bone marrow and chest pain of observation group were 35.4%,22.9% and 18.8%. Compared with control group, the incidence of observation group had significantly lowered. There were signifi-cant differences between the two groups（P〈0.05）. Conclusion Mannatide injection combined with nedaplatin is more efficient and less adverse reaction for malignant pleural effusion, so it is worth popularizing.
出处
《中国现代医生》
2014年第29期16-18,共3页
China Modern Doctor
关键词
甘露聚糖肽
奈达铂
恶性胸腔积液
Mannatide Injection
Nedaplatin
Malignant pleural effusion
