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K63-linked polyubiquitination of IRF1： an essential step in the IL-1 signaling cascade

K63-linked polyubiquitination of IRF1： an essential step in the IL-1 signaling cascade
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摘要 Interleukin 1 （IL-1） is a pleiotropic cytokine that regulates immune and inflammatory responses by inducing the expression of a variety of pro-inflamma- tory cytokines and chemokines. IL-1 exerts its pro-inflammatory effects primarily by activating nuclear factor KB （NF-rB） and mitogen-activated protein kinases （MAPKs）. After binding to its receptor Interleukin 1 （IL-1） is a pleiotropic cytokine that regulates immune and inflammatory responses by inducing the expression of a variety of pro-inflamma- tory cytokines and chemokines. IL-1 exerts its pro-inflammatory effects primarily by activating nuclear factor KB （NF-rB） and mitogen-activated protein kinases （MAPKs）. After binding to its receptor
作者 Tianxiao Wang Jianli Wang
机构地区 Institute of Immunology Clinical Medical College of Shandong University
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2014年第5期407-409,共3页 中国免疫学杂志（英文版）
关键词 IL-1 泛素化 丝裂原活化蛋白激酶 白细胞介素-1 级联 信号 连接 MAPKS
分类号 Q26 [生物学—细胞生物学] S853.74 [农业科学—临床兽医学]
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参考文献15

  • 1Arend WP. The balance between IL-l and IL-lRa in disease. Cytokine Growth Factor Rev 2002; 13:323-340. 被引量：1
  • 2Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-IR-mediated signaling. Trends Biochem Sci 2002; 27: 474-482. 被引量：1
  • 3Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 2007; 204: 1025-1036. 被引量：1
  • 4Inoue J, Gohda J, Akiyama T. Charac?teristics and biological functions of TRAF6. Adv Exp Med Bioi 2007; 597: 72-79. 被引量：1
  • 5Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D et al. Activation of the canonicallKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Nat! Acad Sci USA 2013; 110: 15247-15252. 被引量：1
  • 6Chen ZJ. Ubiquitin signalling in the NF?kappaB pathway. Nat Cell Bioi 2005; 7: 758-765. 被引量：1
  • 7Deng L, Wang C, Spencer E, Yang L, Braun A, You J et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103: 351-361. 被引量：1
  • 8Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-l receptor- and Toll-like receptor-mediated NF-kappaB activation. Mol Cell Bioi 2008; 28: 3538-3547. 被引量：1
  • 9Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T et al. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I I FN production by conventional dendritic cells. J Immunol 2010; 184: 3341-3345. 被引量：1
  • 10Balkhi MY, Fitzgerald KA, Pitha PM. Functional regulation of MyD88-activated interferon regulatory factor 5 by K63- linked polyubiquitination. Mol Cell Bioi 2008;28:7296-7308. 被引量：1
Cellular & Molecular Immunology
2014年 第5期

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