摘要
目的探讨可溶性晚期糖基化终末产物受体(sRAGE)在急性呼吸窘迫综合征(ARDS)患者诊断及预后预测中的价值。方法选取2012年3月—2013年3月入住辽宁医学院附属第一医院重症监护病房的ARDS患者60例为ARDS组,根据氧合指数(PaO2/FiO2)将ARDS组分为轻度ARDS组(23例)、中度ARDS组(23例)及重度ARDS组(14例),根据预后分为死亡组(18例)及存活组(42例);另选择同时期入住重症监护病房的非ARDS患者60例为非ARDS组。采用酶联免疫吸附试验(ELISA)法检测患者血浆sRAGE水平,记录患者PaO2/FiO2。结果ARDS组较非ARDS组患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P<0.05)。不同严重程度ARDS组患者sRAGE水平及PaO2/FiO2比较,差异均有统计学意义(P<0.05);其中中度ARDS组、重度ARDS组较轻度ARDS组,重度ARDS组较中度ARDS组患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P<0.05)。死亡组较存活组ARDS患者sRAGE水平升高,PaO2/FiO2降低,差异有统计学意义(P<0.05)。直线相关性分析显示,ARDS组患者sRAGE水平与PaO2/FiO2呈负相关(r=-0.949,P=0.000 2)。结论 sRAGE在ARDS患者预后预测方面存在价值,可作为评价ARDS预后的一个生化标记物;在诊断方面可能存在一定价值,有待于进一步研究验证。
Objective To discuss the application value about soluble receptor for advanced glycation end products （sRAGE）in the diagnostic and prognostic assessment of patients with acute respiratory distress syndrome（ARDS）in the inten-sive care unit（ICU）. Methods 60 ARDS patients admitted to the First Affiliated Hospital of Liaoning Medical University from March 2012 to March 2013 were selected. The patients were divided into mild group（23 cases）,moderate group（23 cases）and severe group（14 cases）based on oXygenation indeX（PaO2 / FiO2 ）,and were divided into death group（18 cases）and survival group（42 cases）. Another 60 patients admitted to ICU during the same period were selected as non - ARDS group. ELISA meth-od was used to detect sRAGE level,and the PaO2 / FiO2 was also recorded. Results Compared with the non - ARDS group,the ARDS group had higher sRAGE level and lower PaO2 / FiO2（P é 0. 05）. The sRAGE level and PaO2 / FiO2 of ARDS patients with different severities showed statistically significant differences（P é 0. 05）. As for the sRAGE level,the moderate group and severe group were higher than the mild group,and the severe group was higher than the moderate group and mild group,but the PaO2 / FiO2 was just the opposite（P é 0. 05）. The sRAGE level in the death group was higher than the survival group,but the PaO2 / FiO2 was lower（P é 0. 05）. Linear correlation analysis showed that the sRAGE level in ARDS patients was negatively cor-related with PaO2 / FiO2（r = - 0. 949,P = 0. 000 2）. Conclusion Plasma sRAGE is helpful in the diagnosis and prognosis prediction in the ICU. It can be used as a prognostic biochemical marker for ARDS. It may be also helpful in the diagnosis of ARDS,but needs further study to verify.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第22期2603-2606,共4页
Chinese General Practice
基金
辽宁省教育厅科学技术研究项目(2008419)
关键词
呼吸窘迫综合征
成人
可溶性晚期糖基化终末产物
诊断
预后
Respiratory distress syndrome,adult
Soluble receptor for advanced glycation end - products
Diagnosis
Prognosis
