摘要
目的 ：观察华蟾素联合5-氟尿嘧啶治疗肠道肿瘤的临床疗效和安全性。方法：110例肠道肿瘤患者按随机数字表法均分为观察组和对照组。对照组患者给予顺铂注射液40 mg加入5%葡萄糖注射液1 000 ml中d1、3静脉滴注,5-氟尿嘧啶注射液500mg加入0.9%氯化钠注射液1 000 ml中d3-7静脉滴注;观察组患者给予华蟾素注射液20 ml加入5%葡萄糖注射液中500 ml d1-7静脉滴注,5-氟尿嘧啶用法用量同对照组。两组患者均间隔2 d后重复给药1次,3次为1个周期,治疗3个周期后评价疗效、毒性反应及生存率。结果：观察组患者总有效率、生存率、0~Ⅰ级毒性反应发生率显著高于对照组,Ⅱ~Ⅳ毒性反应发生率显著低于对照组,差异均有统计学意义（P〈0.05）。结论：华蟾素联合5-氟尿嘧啶治疗肠道肿瘤较顺铂联合5-氟尿嘧啶疗效更显著,且安全性较好,可提高患者生存质量。
OBJECTIVE：To observe clinical efficacy and safety of cinobufacini combined with 5-fluorouracl in the treatment for intestinal tumor. METHODS：110 patients with intestinal tumor were randomly divided into observation group and control group. Control group was given Cisplatin injection 40 mg added into 5% Glucose injection 1 000 ml intravenously d1,d3,and 5-fluorouracl added into 0.9% Sodium chloride injection 1 000 ml intravenously d3-7. Observation group was given Cinobufacini injection20 ml added into 5% Glucose injection 500 ml intravenously d1-7（same usage and dosage as control group）. Both groups were given drugs every 2 days,3 times as a treatment cycle. Clinical efficacy,toxicity reaction and survival rate of 2 groups were evaluated after 3 treatment cycles. RESULTS：Total effective rate,survival and the incidence of grade 0-Ⅰtoxic reaction in observation group were significantly higher than in control group,but the incidence of grade Ⅱ-Ⅳtoxic reaction was significantly lower than in control group;there was statistical significance（P〈0.05）. CONCLUSIONS：Cinobufacini combined with 5-Fluorouracl has a certain clinical effect for intestinal tumor. It is safe and can improve the quality of life.
出处
《中国药房》
CAS
CSCD
2014年第36期3415-3417,共3页
China Pharmacy
关键词
华蟾素注射液
5-氟尿嘧啶注射液
肠道肿瘤
疗效
安全性
Cinobufacini injection
5-Fluorouracl injection
Intestinal tumor
Therapeutic efficacy
Safety
