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二甲双胍分别联合艾塞那肽及沙格列汀治疗2型糖尿病的疗效及HbA1c达标率比较 被引量:3

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摘要 目的探讨二甲双胍分别联合艾塞那肽与沙格列汀治疗2型糖尿病(T2DM)的疗效及对血清HbA1c水平的影响。方法将该院收治的T2DM患者118例随机分为艾塞那肽组和沙格列汀组各59例。艾塞那肽组给予艾塞那肽联合二甲双胍,沙格列汀组给予沙格列汀联合二甲双胍治疗。观察2组治疗前后的糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2h血糖(2hPG)、血压及体质量等指标的变化,评价治疗效果。结果治疗后2组患者的HbA1c、FBG、2hPG、收缩压、舒张压、体质量较治疗前均下降(P<0.05),且艾塞那肽组的HbA1c、FBG、2hPG、收缩压及体质量下降幅度明显高于沙格列汀组(P<0.05)。结论艾塞那肽与沙格列汀分别联合二甲双胍均可有效降低HbA1c的水平并控制T2DM患者血糖,但艾塞那肽更能有效改善HbA1c及血糖水平,更有利于控制血压和体质量。
出处 《临床合理用药杂志》 2014年第28期36-37,共2页 Chinese Journal of Clinical Rational Drug Use
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