摘要
目的探讨血管紧张素-(1-7)[Ang-(1-7)]及贝那普利对大鼠慢性心力衰竭(CHF)后心肌重构及心功能的影响。方法制作CHF模型雄性SD大鼠45只,随机分CHF组、Ang-(1-7)治疗组、Ang-(1-7)及贝那普利联合治疗组,另设15只为正常对照组,给药4周后检测血流动力学及心功能参数,检测大鼠心脏左室重量、左室重量指数及左室截面直径。结果与正常对照组比较,CHF组左室重量及左室重量指数、左室截面直径明显增大(P<0.01),左室收缩压及左室内压最大上升和下降速率下降(P<0.01);与CHF组比较,Ang-(1-7)治疗组左室重量及左室重量指数、左室截面积直径减小(P<0.01),左室收缩压及左室内压最大上升和下降速率升高(P<0.01);与Ang-(1-7)治疗组比较,联合用药组左室重量及左室重量指数、左室截面积直径减小(P<0.05),左室收缩压及左室内压最大上升和下降速率升高(P<0.01))。结论 Ang-(1-7)可以改善CHF后心肌重构,与贝那普利联合应用改善CHF后心肌重构的作用更明显。
Objective To investigate the influence of angiotensin-（1-7） [Ang-（1-7）] and benazepril on the myocardial remodeling and cardiac function of rats with chronic heart failure. Methods Chronic heart failure （CHF） model of 45 male SD rats was built and the rats were randomly divided into the CHF group,the Ang-（1-7） treatment group and the Ang-（1-7） and benazepril combination treatment group.And 15 normal rats were assigned to the control group.After 4 weeks of administration,the hemodynamic and cardiac function parameters were detected and the left ventricular weight,left ventricular mass index and left ventricular cross-sectional diameter of the rats were detected. Results Compared to the normal control group,the left ventricular weight,left ventricular mass index and left ventricular cross-sectional diameter of the CHF group increased significantly （P〈0.01） and the left ventricular systolic pressure and left ventricular pressure maximum rise and fall rates decreased （P〈0.01）.Compared to the CHF group,the left ventricular weight,left ventricular mass index and left ventricular cross-sectional diameter of the Ang-（1-7） treatment group decreased significantly （P〈0.01） and the left ventricular systolic pressure and left ventricular pressure maximum rise and fall rates increased （P〈0.01）.Compared to the Ang-（1-7） treatment group,the left ventricular weight,left ventricular mass index and left ven-tricular cross-sectional diameter of the combination treatment group decreased significantly （P〈0.05） and the left ven-tricular systolic pressure and left ventricular pressure maximum rise and fall rates increased （P〈0.01）. Conclusion Ang-（1-7） can improve the cardiac remodeling of CHF and its cardiac remodeling effect is more obvious when com-bined with benazepril.
出处
《中国当代医药》
2014年第28期14-16,共3页
China Modern Medicine
