摘要
组蛋白修饰是表观遗传学的重要组成部分,其在甲状腺癌的诊断、治疗等方面的研究越来越多.甲基化、乙酰化、磷酸化及泛素化组蛋白修饰均可参与甲状腺癌的发生.组蛋白修饰可参与调控甲状腺癌细胞的分化,影响肿瘤细胞的增殖.组蛋白去乙酰化酶抑制剂可用于甲状腺癌的治疗.
Histone modification is one of the major forms of epigenetic modifications,there are more and more researches on the applications of histone modifications in the diagnosis and treatment of thyroid tumor.Methylation,acetylation,phosphorylation and ubiquitin of histone modification involve in thyroid cancer.Histone modification can regulate the differentiation of thyroid cancer,influence the proliferation of tumor cells.Histone deacetylases may be used in the treatment of thyroid tumors.
出处
《国际内分泌代谢杂志》
北大核心
2014年第5期348-350,359,共4页
International Journal of Endocrinology and Metabolism
基金
基金项目：国家自然科学基金资助项目（81170759）
