摘要
气道损伤时,伤口愈合过程异常是导致肥厚性瘢痕形成和气道管腔狭窄的原因,愈合过程可分为3个阶段：炎症期、增生期及成熟期.针对不同愈合阶段,所应用的预防和治疗瘢痕形成及气道狭窄的药物是不同的.具体包括：抗生素和类固醇、丝裂霉素、紫杉醇、5-氟尿嘧啶/氟羟强的松龙结合物、卤夫酮、抗反流药物、免疫抑制剂、生长因子等.本文综述了上述药物在细胞、动物及临床试验中治疗气道狭窄的作用、安全性及应用前景.
When the airway is injuried,abnormal wound-healing process can lead to hypertrophic scar formation and narrowing of the airway lumen.The wound-healing process includes three overlapping phases：inflammation,proliferation,and maturation.At different phases,the drugs used to prevent and treat scar formation and narrowing of the airway lumen are different.The drugs conclude antibiotics and steroids,mitomycin,paclitaxel,5-fluorouracil/triamcinolone conjugate,halofuginone,antireflux drugs,immunodepressant,and growth factor,etc.This review summarizes the therapy effect,safety,and prospect of these drugs.
出处
《国际呼吸杂志》
2014年第18期1414-1420,共7页
International Journal of Respiration
