摘要
目的 评价丙泊酚联合依托咪酯用于心脏电复律（cardioversion）术的麻醉效果.方法 将60例行心脏电复律术的患者随机分为丙泊酚组（P组）22例、依托咪酯组（E组）18例、依托咪酯＋丙泊酚组（P＋E组）20例,分别应用丙泊酚和（或）依托咪酯进行麻醉,术后5 min、30 min和2h分别观察患者基础生命体征、反应程度、镇静评分和不良反应发生情况等.结果 各组血流动力学指标、Ramsay评分及电复律有效率无明显差别（P＞0.05）;P＋E组电复律时1度、2度和3度体动反应发生率分别为85％、15％、0,较P组及E组明显减少（P＜0.05）.E组术后恶心、呕吐、肌颤、呼吸抑制发生率分别为38.9％、44.4％、72.2％、11.1％,较P组明显增加（P＞0.05）,P＋E组术后恶心、呕吐发生率与P组比较差异无统计学意义,肌颤和呼吸抑制的发生率分别为5％和10％,较P组减少（P＜0.05）.结论 丙泊酚联合依托咪酯用于心脏电复律麻醉血流动力学平稳,不良反应少.
Objective To evaluate the anesthetic effects of combined use of propofol and etomidate on cardioversion. Methods Sixty patients were randomly divided into three groups before receiving cardioversion： a Propofol group （ n = 22 ） , an Etomidate group （ n = 18 ） and a Propofol ＋ Etomidate group （ n = 20 ）. After treatment with propofol or etomidate or both, vital signs, sedative scores and adverse reactions of the patients were recorded. Results No signifi- cant differences were found as to hemodynamic parameters, Ramsay scores and the successful rate of electrical eardiover- sion among the three groups （P 〉 0.05）. For the P ＋ E group, their first - degree, second - degree and third degree rates of movement were 85% , 15% and 0, respectively, which were remarkably lower than those of either the P group or E group （P 〈0.05）. The E group reported nausea （38.9%） , vomiting （44.4%） , muscle twitching （72.2%） and re- spiratory inhibition （ 11.1% ）, which were more frequent than the P group （ P 〈 0.05 ）. No significant differences were found as to the rates of nausea and vomiting between the P group and the P ＋ E group. However, the P ＋ E group showed 5% of muscle twitching and 10% of respiratory inhibition which were less frequent than those in the P group （ P 〈 0.05 ）. Conclusion Combined use of propofol and etomidate can be applied for anesthesia for eardioversion, with stable hemodynamie responses and less adverse reactions.
出处
《徐州医学院学报》
CAS
2014年第8期496-499,共4页
Acta Academiae Medicinae Xuzhou
基金
国家自然科学基金（31100801,81200858）
