帕瑞昔布治疗瑞芬太尼术后痛觉过敏的效果观察被引量：1

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摘要目的观察帕瑞昔布治疗瑞芬太尼术后痛觉过敏的效果。方法 80例行腹腔镜手术的妇科患者,随机分为帕瑞昔布组和芬太尼组,每组40例。帕瑞昔布组患者在手术结束前30 min予帕瑞昔布(0.8 mg/kg),芬太尼组则予芬太尼(1g/kg)。记录并比较两组患者的自主呼吸恢复时间、意识恢复时间、拔管时间、拔管后疼痛程度。结果帕瑞昔布组患者的自主呼吸恢复时间、意识恢复时间、拔管时间比芬太尼组短(P<0.01),两组患者拔管后的疼痛程度差异无统计学意义(P>0.05)。结论帕瑞昔布治疗瑞芬太尼术后痛觉过敏的效果好,不良反应少。

作者陈玲坤苏薇莫朴

机构地区广东省茂名市人民医院麻醉科

出处《广东医学院学报》 2014年第2期205-206,共2页 Journal of Guangdong Medical College

关键词帕瑞昔布瑞芬太尼痛觉过敏

分类号 R971.2 [医药卫生—药品]

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1Cooper Z D, Truong Y N, Shi Y G, et al. Morphine deprivationincreases self- administration of the fast- and short-acting mu-opioidreceptor agonist remifentanil in the rat[J]. J Pharmacol Exp Ther,2008, 326(3):920-929. 被引量：1
2Lenz H,Raeder J,Hoymork S C, et al. Administration of fentanylbefore remifentanil- based anaesthesia has no influence on post-operative pain or analgesic consumption[J], Acta Anaesthesiol Scand,2008, 52(1):149-154. 被引量：1
3Lee M, Silverman S M, Hansen H, et al. A comprehensive review ofopioid-induced hyperalgesia[J]. Pain Physician, 2011, 14(2):145-161. 被引量：1
4Hang L H,Shao D H, Gu Y P, et al. The ED50 and ED95 of ketaminefor prevention of postoperative hyperalgesia after remifentanil-basedanaesthesia in patients undergoing laparoscopic cholecystectomy[J].Swiss Med Wkly,2011, 141:wl3195. 被引量：1
5杭黎华,邵东华,王洪,周蓓,黄霞萍,顾月萍.氯胺酮减轻雷米芬太尼致术后痛觉过敏的半数有效量[J].临床麻醉学杂志,2010,26(2):113-114. 被引量：12
6周莉莉,顾晓萍.帕瑞昔布钠对复合瑞芬太尼全麻妇科腹腔镜手术术后急性疼痛和痛觉过敏的影响[J].徐州医学院学报,2012,32(8):542-545. 被引量：6
7Lenz H, Raeder J, Draegni T, et al. Effects of COX inhibition onexperimental pain and hyperalgesia during and after remifentanilinfusion in hutnans[J]. Pain, 2011, 152(6):1289-1297. 被引量：1

二级参考文献18

1Cortinas Sáenz M,Gerónimo Pardo M,Cortinas Sáenz M,et al.Acute opiate tolerance and postoperative hyperalgesia after a brief infusion of remifentanil managed with multimodal analgesia.Rev Esp Anestesiol Reanim,2008,55:40-42. 被引量：1
2Chang G,Chen L,Mao JR.Opioid tolerance and hyperalgesia.Medical Clinics of North America,2007,91:199. 被引量：1
3Guntz E,Talla G,Roman A,et al.Opioid-induced hyperalgesia.Eur J Anaesthesiol,2007,24:205-207. 被引量：1
4Joly V,Richebe P,Guignard B,et al.Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine.Anesthesiology,2005,103:147-155. 被引量：1
5Cooper Z,Truong Y,Shi Y,et al.Morphine deprivation increases self-administration of the fast-and short-acting muopioid receptor agonist remifentanil in the rat.J Pharmacot Exp Ther,2008,326:920-929. 被引量：1
6Hansen EG,Duedahl TH,Romaing J,et al.Intra-operative remifentanil might influence pain levels in the immediate postoperative period after major abdominal surgery.Acta Anaesthesiologica Scandinavica,2005,49:1464-1470. 被引量：1
7Lenz H,Raeder J,Hoymork S,Administration of fentanyl before remifentanil-based anaesthesia has no influence on postoperative pain or analgesic consumption.Acta Anaesthesiol Scand,2008,52:149-154. 被引量：1
8Chu LF,Angst MS,Clark D.Opioid-indueed hyperalgesia in humans -Molecular mechanisms and clinical considerations.Clinical Journal of Pain,2008,24:479-496. 被引量：1
9Apfelbaum JL, Lichtor JL, Lane BS, et al. Awakening, clinical recovery, and psychomotor effects after desflurane and propofol an- esthesia [J]. Anesth Analg, 1996,83 (4) :721 - 725. 被引量：1
10Joly V, Richebe P, Guignard B, et al. Remifentanil - induced postoperative hyperalgesia and its prevention with small - dose ket- amine [ J ]. Anesthesiology, 2005,103 ( 1 ) : 147 - 155. 被引量：1