摘要
卵泡发育障碍是导致卵巢早衰(POF)、多囊卵巢综合征(PCOS)、闭经、功血等女性内分泌方面疾病的重要发病环节。颗粒细胞作为卵泡的功能单位,参与了卵泡生长、发育及闭锁的全过程,对卵泡的发育至关重要。从颗粒细胞增殖分化的角度,探讨补肾中药调节卵泡发育的细胞及分子机制,了解其在调节卵泡微环境过程所起的作用,对于中医药的临床应用及实验研究具有重要意义。
Follicular developmental disorder leads to POF, PCOS＇amenorrhea, DUB and other endocrine diseases. As functional units, follicular granulosa cells are involved in the growth, development and atresia of the whole process. From the perspective of granulosa cell proliferation and differentiation, we will explore the Bushen Decoction regulating cellular and molecular mechanisms in follicular development, and investigate the role of it in the follicular microenvironment. It is significant for clinical application of Chinese traditional medicine and experimental study.
出处
《辽宁中医药大学学报》
CAS
2014年第9期120-122,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然基金项目(81303123)
中国博士后基金项目(2013T60770)
湖南省自然科学基金项目(11JJ4075)
高等学校博士学科点专项科研基金项目(20114323120007)
关键词
补肾中药
卵泡发育
颗粒细胞
卵泡微环境
综述
Bushen Decoction
follicular development disorders
granulosa cell
follicularmicroenvironment
review
