摘要
目的探讨急性心肌梗死(AMI)急诊经皮冠状动脉介入治疗(PCI)后无复流现象与氨基末端脑钠肽前体(NT-pro BNP)的关系。方法检测70例AMI患者PCI术出现无复流组和再灌注组术前外周静脉血超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、NT-pro BNP的水平。结果比较无复流组和再灌注组的hs-CRP、D-D、NT-pro BNP值,无复流组的hs-CRP(25.44±19.95)mg·L-1、D-D(537.47±165.07)μg·L-1、NT-pro BNP(1 350.71±658.07)ng·L-1,水平PCI术前明显高于再灌注组hs-CRP(5.31±1.91)mg·L-1、D-D(363.91±225.65)μg·L-1、NT-pro BNP(496.81±240.13)ng·L-1水平(均P<0.05)。无复流AMI患者NT-pro BNP与hs-CRP有明显相关关系(r=0.973,P<0.05),与D-D有明显相关关系(r=0.972,P<0.05)。而再灌注AMI患者NT-pro BNP与hs-CRP无明显相关关系(r=-0.199,P>0.05),与D-D无明显相关关系(r=-0.077,P>0.05)。结论急性心肌梗死急诊PCI术无复流现象的发生与NT-pro BNP密切相关。
Objective To investigate the correlation of the no-reflow phenomenon with N-terminal pro-brain natriuretic peptide after percutaneous coronary intervention for acute myocardial infarction. Methods The plasma NT-proBNP,hs-CRP and D-D levels in 70 patients with acute myocardial infarction before percutaneous coronary intervention were tested. The patients were divided into no-reflow group and reperfusion group. Results The plasma hs-CRP （25. 44±19. 95） mg·L-1,D-D（537. 47±165. 07） μg·L-1 and NT-proBNP（1350. 71±658. 07） ng·L-1 levels in no-reflow group were significantly higher than the levels of hs-CRP （5. 31±1. 91） mg ·L-1,D-D（363. 91±225. 65） μg·L-1 and NT-proBNP（496. 81±240. 13） ng·L-1 in reperfusion group （P〈0. 05）. There was significant correlation between NT-proBNP and D-D（r=0. 973,P〈0. 05）in no-reflow group,so did NT-proBNP and D-D （r=0. 972, P〈0.05）.However,there was no significant correlation between NT-proBNP and hs-CRP（r = -0.199,P 〉0.05）in reperfusion group,so did NT-proBNP and D-D（r= -0. 077,P〉0. 05）. Conclusions N-terminal pro-brain natriuretic peptide is closely associat-ed with the no-reflow phenomenon after percutaneous coronary intervention for acute myocardial infarction.
出处
《安徽医药》
CAS
2014年第11期2091-2093,共3页
Anhui Medical and Pharmaceutical Journal
基金
南京军区医药卫生科研基金(No 10MA059)
关键词
急性心肌梗死
脑钠肽前体
无复流
超敏C反应蛋白
D-二聚体
acute myocardial infarction
N-terminal pro-brain natriuretic peptide
no-reflow
high sensitivity C-reactive protein
d-dimer
